Opioid Receptor-Mu (MOR) Antibody

Opioid Receptor-Mu (MOR) Antibody
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Price: $375.00
Product ID : 24216

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Description

The ImmunoStar Mu Opioid Receptor antiserum was quality control tested using standard immunohistochemical methods. The antiserum demonstrates strongly positive labeling of rat caudate putamen and spinal cord (dorsal horn) using indirect immunofluorescent and biotin/avidin-HRP techniques. Recommended primary dilution is 1/6000 - 1/10000 in PBS/0.3% Triton X-100 - Biotin/avidin-HRP Technique.

Preadsorption with MOR peptide (384-398) at 10 µg/ml completely eliminates labeling. The specificity of the antiserum was determined by immunolabeling of transfected cells, Western Blot analysis and immunoisolation studies.

Photo Description: IHC image of mu opioid receptor staining in the rat striatum. The tissue was fixed with 4% formaldehyde in phosphate buffer, before being removed and prepared for vibratome sectioning. Floating sections were incubated at RT in 10% goat serum in PBS, before standard IHC procedure. Primary antibody was incubated at 1:10000 for 48 hours, goat anti-rabbit secondary was subsequently added for 1 hour after washing with PBS. Light microscopy staining was achieved with standard biotin-streptavidin/HRP procedure and DAB chromogen.

Host: Rabbit

Quantity / Volume:  100 µL

State: Lyophilized Whole Serum

Reacts With:  Cat, Chicken, Frog, Guinea Pig, Human, Monkey, Mouse, Rat, Starling, Tadpole

Availability: In Stock

Alternate Names:  MOR-1; Mu-type opioid receptor; M-OR1; Mu opiate receptor; Opioid receptor B; MUOR1; M-OR-1; MORA; oprm; opioid receptor, mu 1, anti-MOR

Gene Symbol / ID, Accession #:  Oprm1, 25601

RRID:  AB_572251

Reviews

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Reviewed by marvizon
12/09/2015 - 07:21:16 PM
MOR antibody 24216

This is an excellent antibody to label MORs in the rat spinal cord using immunofluorescence. I have used it to study MOR internalization induced by opioid release in the following papers:
Chen W, Marvizon JC (2009) Acute inflammation induces segmental, bilateral, supraspinally mediated opioid release in the rat spinal cord, as measured by µ-opioid receptor internalization. Neuroscience 161:157-172.
Chen W, Song B, Lao L, Perez OA, Kim W, Marvizon JCG (2007) Comparing analgesia and µ-opioid receptor internalization produced by intrathecal enkephalin: Requirement for peptidase inhibition. Neuropharmacology 53:664-667.
Chen W, Song B, Marvizon JC (2008a) Inhibition of opioid release in the rat spinal cord by a2C adrenergic receptors. Neuropharmacology 54:944-953.
Chen W, Song B, Zhang G, Marvizon JC (2008b) Effects of veratridine and high potassium on µ-opioid receptor internalization in the rat spinal cord: stimulation of opioid release versus inhibition of internalization. J Neurosci Methods 170:285-293.
Marvizon JC, Grady EF, Waszak-McGee J, Mayer EA (1999) Internalization of m-opioid receptors in rat spinal cord slices. Neuroreport 10:2329-2334.
Song B, Chen W, Marvizon JC (2007) Inhibition of opioid release in the rat spinal cord by serotonin 5-HT1A receptors. Brain Res 1158:57-62.
Song B, Marvizon JC (2003a) Peptidases prevent m-opioid receptor internalization in dorsal horn neurons by endogenously released opioids. J Neurosci 23:1847-1858.
Song B, Marvizon JCG (2003b) Dorsal horn neurons firing at high frequency, but not primary afferents, release opioid peptides that produce m-opioid receptor internalization in the rat spinal cord. J Neurosci 23:9171-9184.
Song B, Marvizon JCG (2005) NMDA receptors and large conductance calcium-sensitive potassium channels inhibit the release of opioid peptides that induce m-opioid receptor internalization in the rat spinal cord. Neuroscience 136:549-562.
Walwyn W, Chen W, Kim H, Minasyan A, Ennes H, McRoberts JA, Marvizon JC (2016) Sustained suppression of hyperalgesia during latent sensitization by µ, δ and κ opioid receptors and α2A adrenergic receptors - role of constitutive activity. J Neurosci (in press).

I have tried other MOR antibodies but this is by far the best.

Publications

PROD # ANTIBODY CITATION SPECIES REACTIVITY APPL METHOD RESEARCH AREA # CITED BY PUBMED ID
24216 Opioid Receptor-Mu (MOR) Antibody Development. 2001 Dec;128(23):4769-80. A role for Gsh1 in the developing striatum and olfactory bulb of Gsh2 mutant mice.Toresson H1, Campbell K. Mouse IHC 114 11731457
24216 Opioid Receptor-Mu (MOR) Antibody J Neurosci. 2011 Nov 16;31(46):16757-69. doi: 10.1523/JNEUROSCI.2628-11.2011. A novel functionally distinct subtype of striatal neuropeptide Y interneuron. Ibáñez-Sandoval O1, Tecuapetla F, Unal B, Shah F, Koós T, Tepper JM. Mouse WB 21490202
24216 Opioid Receptor-Mu (MOR) Antibody Patierno, S., H. E. Raybould, and C. Sternini. "Abdominal surgery induces ? opioid receptor endocytosis in enteric neurons of the guinea-pig ileum." Neuroscience 123.1 (2004): 101-109. Guinea Pig IHC 16 14667445
24216 Opioid Receptor-Mu (MOR) Antibody Song, Bingbing, Wenling Chen, and Juan Carlos G. Marviz, Ability of veratridine and high potassium to produce -opioid receptor internalization by evoking the release of opioid peptides in the rat spinal cord 0 not found
24216 Opioid Receptor-Mu (MOR) Antibody McConalogue, K., et al. "Activation and internalization of the?-opioid receptor by the newly discovered endogenous agonists, endomorphin-1 and endomorphin-2." Neuroscience 90.3 (1999): 1051-1059. 86 10218804
24216 Opioid Receptor-Mu (MOR) Antibody Horner, Kristen A., et al. "Activation of mu opioid receptors in the striatum differentially augments methamphetamine?induced gene expression and enhances stereotypic behavior." Journal of neurochemistry 120.5 (2012): 779-794. Rat IHC 3 22150526
24216 Opioid Receptor-Mu (MOR) Antibody Coolen LM1, Fitzgerald ME, Yu L, Lehman MN, Neuroscience. 2004;124(1):11-21. "Activation of mu opioid receptors in the medial preoptic area following copulation in male rats" Rat ICC 42 14960335
24216 Opioid Receptor-Mu (MOR) Antibody J Neurosci Res. 2004 Aug 1;77(3):323-33.Activity-regulated cytoskeleton-associated protein Arc is targeted to dendrites and coexpressed with mu-opioid receptors in postnatal rat caudate-putamen nucleus.Wang H1, Pickel VM. Rat ICC 10 15248288
24216 Opioid Receptor-Mu (MOR) Antibody Chen W1, Marvizón JC, Neuroscience. 2009 Jun 16;161(1):157-72. doi: 0.1016/j.neuroscience .2009.03.021. Epub 2009 Mar 17. "Acute inflammation induces segmental, bilateral, supraspinally mediated opioid release in the rat spinal cord, as measured by mu-opioid receptor internalization" Rat IHC 15 19298846
24216 Opioid Receptor-Mu (MOR) Antibody Xu, Y., et al. "Adeno-associated viral transfer of opioid receptor gene to primary sensory neurons: a strategy to increase opioid antinociception." Proceedings of the National Academy of Sciences 100.10 (2003): 6204-6209. Rat viral 61 12719538
24216 Opioid Receptor-Mu (MOR) Antibody Nature. 2008 Jul 31;454(7204):642-5. doi: 10.1038/nature07167. Epub 2008 Jul 9.Amygdala intercalated neurons are required for expression of fear extinction.Likhtik E1, Popa D, Apergis-Schoute J, Fidacaro GA, Paré D. Rat IHC 18615014
24216 Opioid Receptor-Mu (MOR) Antibody Abbadie, C., et al. "Anatomical and functional correlation of the endomorphins with mu opioid receptor splice variants." European Journal of Neuroscience 16.6 (2002): 1075-1082. Mouse IHC 29 12383236
24216 Opioid Receptor-Mu (MOR) Antibody Horner, K. A., et al. "Blockade of stimulant-induced preprodynorphin mRNA expression in the striatal matrix by serotonin depletion." Neuroscience 131.1 (2005): 67-77. Rat 18 15680692
24216 Opioid Receptor-Mu (MOR) Antibody Guo, Wei, et al. "Bone Marrow Stromal Cells Produce Long?Term Pain Relief in Rat Models of Persistent Pain." Stem Cells 29.8 (2011): 1294-1303. Rat IHC 9 21630378
24216 Opioid Receptor-Mu (MOR) Antibody Han, Ming-Hi, et al. "Brain region specific actions of regulator of G protein signaling 4 oppose morphine reward and dependence but promote analgesia." Biological psychiatry 67.8 (2010): 761-769. Mouse IP, WB 25 19914603
24216 Opioid Receptor-Mu (MOR) Antibody Lane, Diane A., et al. "Cannabinoid?1 receptor gene deletion has a compartment?specific affect on the dendritic and axonal availability of ??opioid receptors and on dopamine axons in the mouse nucleus accumbens." Synapse 64.12 (2010): 886-897. Mouse 7 20939059
24216 Opioid Receptor-Mu (MOR) Antibody Fehrenbacher, Jill C., et al. "Capsaicin-evoked iCGRP release from human dental pulp: a model system for the study of peripheral neuropeptide secretion in normal healthy tissue." Pain 144.3 (2009): 253-261. Human IHC 21 19428185
24216 Opioid Receptor-Mu (MOR) Antibody Salio, C., et al. "CB1 cannabinoid receptors in amphibian spinal cord: relationships with some nociception markers." Journal of chemical neuroanatomy 24.3 (2002): 153-162. 26 12297261
24216 Opioid Receptor-Mu (MOR) Antibody Nguyen, Khanh, and Bonnie C. Miller. "CD28 costimulation induces ? opioid receptor expression during anti-CD3 activation of T cells." The Journal of Immunology 168.9 (2002): 4440-4445. Mouse WB 21 11970987
24216 Opioid Receptor-Mu (MOR) Antibody Milner, Teresa A., Carrie T. Drake, and Sue A. Aicher. "Cellular relations between ?-opioid receptive, GABAergic and reticulospinal neurons in the rostral ventrolateral medulla." Brain research 917.1 (2001): 1-14. 12 11602225
24216 Opioid Receptor-Mu (MOR) Antibody Cenci, M. A., et al. "Changes in the regional and compartmental distribution of FosB-and JunB-like immunoreactivity induced in the dopamine-denervated rat striatum by acute or chronic L-dopa treatment." Neuroscience 94.2 (1999): 515-527. 92 10579213
24216 Opioid Receptor-Mu (MOR) Antibody He, Li, and Jennifer L. Whistler. "Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis." PloS one 6.5 (2011): e19372. Rat IHC 6 21602922
24216 Opioid Receptor-Mu (MOR) Antibody Ding, Yu-Qiang, et al. "Co-localization of-opioid receptor-like immunoreactivity with substance P-LI, calcitonin gene-related peptide-LI and nitric oxide synthase-LI in vagal and glossopharyngeal afferent neurons of the rat." Brain research 792.1 (1998): 149-153. Rat 23 9593869
24216 Opioid Receptor-Mu (MOR) Antibody Chen W1, Song B, Lao L, Pérez OA, Kim W, Marvizón JC, Neuropharmacology. 2007 Oct;53(5):664-76. Epub 2007 Aug 2. "Comparing analgesia and mu-opioid receptor internalization produced by intrathecal enkephalin: requirement for peptidase inhibition" Rat IHC 25 17845806
24216 Opioid Receptor-Mu (MOR) Antibody Vanderschuren, Louk JMJ, et al. "Compartment-specific changes in striatal neuronal activity during expression of amphetamine sensitization are the result of drug hypersensitivity." European Journal of Neuroscience 16.12 (2002): 2462-2468. Rat IHC 36 12492441
24216 Opioid Receptor-Mu (MOR) Antibody Miura, Masami, et al. "Compartment-specific modulation of GABAergic synaptic transmission by ?-opioid receptor in the mouse striatum with green fluorescent protein-expressing dopamine islands." The Journal of Neuroscience 27.36 (2007): 9721-9728. Mouse 43 17804632
24216 Opioid Receptor-Mu (MOR) Antibody Capper-Loup, Christine, et al. "Concurrent activation of dopamine D1 and D2 receptors is required to evoke neural and behavioral phenotypes of cocaine sensitization." The journal of neuroscience 22.14 (2002): 6218-6227. Rat IHC 75 12122080
24216 Opioid Receptor-Mu (MOR) Antibody Huerta-Ocampo, Icnelia, Juan Mena-Segovia, and J. Paul Bolam. "Convergence of cortical and thalamic input to direct and indirect pathway medium spiny neurons in the striatum." Brain Structure and Function (2013): 1-14. 4 23832596
24216 Opioid Receptor-Mu (MOR) Antibody Carlsson, Christer P., Frank Sundler, and Joanna Wallengren. "Cutaneous innervation before and after one treatment period of acupuncture." British Journal of Dermatology 155.5 (2006): 970-976. Human 15 17034527
24216 Opioid Receptor-Mu (MOR) Antibody Wouterlood, Floris G., et al. "Density gradients of vesicular glutamate?and GABA transporter?immunoreactive boutons in calbindin?and ??opioid receptor?defined compartments in the rat striatum." Journal of Comparative Neurology 520.10 (2012): 2123-2142. Rat IHC 4 22173881
24216 Opioid Receptor-Mu (MOR) Antibody Salemi, Souzan, et al. "Detection of kappa and delta opioid receptors in skin IHC 31 16263089
24216 Opioid Receptor-Mu (MOR) Antibody J Comp Neurol. 2009 Mar 1;513(1):21-37. doi: 10.1002/cne.21919. Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome. Stillman AA1, Krsnik Z, Sun J, Rasin MR, State MW, Sestan N, Louvi A. Mouse WB, IF 19105198
24216 Opioid Receptor-Mu (MOR) Antibody Burke, Paul A., et al. "Device for the sustained release of aggregation-stabilized, biologically active agent." U.S. Patent No. 6,514,533. 4 Feb. 2003. 2 not found
24216 Opioid Receptor-Mu (MOR) Antibody Abbadie, Catherine, and Gavril W. Pasternak. "Differential in vivo internalization of MOR-1 and MOR-1C by morphine." Neuroreport 12.14 (2001): 3069-3072. IHC 61 11568638
24216 Opioid Receptor-Mu (MOR) Antibody Deng, Y. P., et al. "Differential localization of the GluR1 and GluR2 subunits of the AMPA-type glutamate receptor among striatal neuron types in rats." Journal of chemical neuroanatomy 33.4 (2007): 167-192. Rat IF 27 17446041
24216 Opioid Receptor-Mu (MOR) Antibody Horner, Kristen A., Yamiece E. Gilbert, and Erika S. Noble. "Differential regulation of 5-HT< 2A< receptor mRNA expression following withdrawal from a chronic escalating dose regimen of d-amphetamine." Brain research 1390 (2011): 10-20. 4 21420940
24216 Opioid Receptor-Mu (MOR) Antibody Horner, Kristen A., Erika S. Noble, and Edward C. Lauterbach. "Differential regulation of prodynophin, c?fos, and serotonin transporter mRNA following withdrawal from a chronic, escalating dose regimen of D?amphetamine." Synapse 63.4 (2009): 257-268. Rat IHC 8 19116947
24216 Opioid Receptor-Mu (MOR) Antibody Narita, Minoru, et al. "Direct evidence for the activation of phospholipase C?1 by in vivo treatment with morphine in the mouse periaqueductal gray matter." Brain research 970.1 (2003): 140-148. Mouse 14 12706255
24216 Opioid Receptor-Mu (MOR) Antibody Adams, David H., Glen R. Hanson, and Kristen A. Keefe. "Distinct effects of methamphetamine and cocaine on preprodynorphin messenger RNA in rat striatal patch and matrix." Journal of neurochemistry 84.1 (2003): 87-93. Rat IHC 29 12485404
24216 Opioid Receptor-Mu (MOR) Antibody Unal B1, Ibáñez-Sandoval O, Shah F, Abercrombie ED, Tepper JM., Front Syst Neurosci. 2011 Jun 6;5:41. doi: 10.3389/fnsys.2011.00041. eCollection 2011. Distribution of tyrosine hydroxylase-expressing interneurons with respect to anatomical organization of the neostriatum. Mouse ICC 6 21713112
24216 Opioid Receptor-Mu (MOR) Antibody Kim, Douglas S., Glenda J. Froelick, and Richard D. Palmiter. "Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum." The Journal of neuroscience 22.22 (2002): 9841-9849. Mouse IHC 30 12427840
24216 Opioid Receptor-Mu (MOR) Antibody J Neurosci. 2003 Oct 8;23(27):9171-84. Dorsal horn neurons firing at high frequency, but not primary afferents, release opioid peptides that produce micro-opioid receptor internalization in the rat spinal cord. Song B1, Marvizón JC. Rat IHC 31 14534251
24216 Opioid Receptor-Mu (MOR) Antibody Lu, Kuan-Ming, et al. "Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity." Proceedings of the National Academy of Sciences 111.1 (2014): E168-E177. Rat 0 24351932
24216 Opioid Receptor-Mu (MOR) Antibody Gracy, K. Noelle, Adena L. Svingos, and Virginia M. Pickel. "Dual ultrastructural localization of ?-opioid receptors and NMDA-type glutamate receptors in the shell of the rat nucleus accumbens." The Journal of neuroscience 17.12 (1997): 4839-4848. Rat ICC 102 9169542
24216 Opioid Receptor-Mu (MOR) Antibody Melendez-Ferro, Miguel, et al. "Dual use of immunohistochemistry for film densitometry and light microscopy." Journal of neuroscience methods 208.1 (2012): 86-91. Rat, Human IHC 2 22579877
24216 Opioid Receptor-Mu (MOR) Antibody Leel, Chun?Yi, et al. "Dynamic temporal and spatial regulation of mu opioid receptor expression in primary afferent neurons following spinal nerve injury." European Journal of Pain 15.7 (2011): 669-675. Rat WB 14 21310637
24216 Opioid Receptor-Mu (MOR) Antibody GLICKSTEIN, SARA B., and CLAUDIA SCHMAUSS. "Effect of methamphetamine on cognition and repetitive motor behavior of mice deficient for dopamine D2 and D3 receptors." Annals of the New York Academy of Sciences 1025.1 (2004): 110-118. Mouse 11 15542707
24216 Opioid Receptor-Mu (MOR) Antibody Wang, Hui-Dong, et al. "Effects of antipsychotic drugs on neurogenesis in the forebrain of the adult rat." Neuropsychopharmacology 29.7 (2004). Rat 136 15085089
24216 Opioid Receptor-Mu (MOR) Antibody Chen, Wenling, et al. "Effects of veratridine and high potassium on ?-opioid receptor internalization in the rat spinal cord: stimulation of opioid release versus inhibition of internalization." Journal of neuroscience methods 170.2 (2008): 285-293. Rat IHC 6 18377995
24216 Opioid Receptor-Mu (MOR) Antibody Guan, Jian-Lian, Qing-Ping Wang, and Yasumitsu Nakai. "Electron microscopic observation of ?-opioid receptor in the rat area postrema?." Peptides 20.7 (1999): 873-880. Rat WB 9 10477089
24216 Opioid Receptor-Mu (MOR) Antibody Van Bockstaele, E. J., et al. "Elevated ??opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate?dependent rats." Journal of neuroscience research 83.3 (2006): 508-514. Rat 14 16385558
24216 Opioid Receptor-Mu (MOR) Antibody Van Bockstaele, E. J., et al. "Elevated ??opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate?dependent rats." Journal of neuroscience research 83.3 (2006): 508-514. Rat 14 16385558
24216 Opioid Receptor-Mu (MOR) Antibody Wang, Qing-Ping, Jian-Lian Guan, and Yasumitsu Nakai. "Endorphinergic innervation of [mu] and [delta] receptor containing neurons in the dorsal raphe nucleus." Neuroreport 9.13 (1998): 3033-3036. 5 9804311
24216 Opioid Receptor-Mu (MOR) Antibody J Comp Neurol. 2006 Jun 20;496(6):859-76.Enkephalinergic afferents of the centromedial amygdala in the rat.Poulin JF1, Chevalier B, Laforest S, Drolet G. Rat 59 16628615
24216 Opioid Receptor-Mu (MOR) Antibody J Comp Neurol. 2009 Nov 1;517(1):51-68. doi: 10.1002/cne.22130. Enkephalins, dynorphins, and beta-endorphin in the rat dorsal horn: an immunofluorescence colocalization study. Marvizón JC1, Chen W, Murphy N. Rat IF 19711397
24216 Opioid Receptor-Mu (MOR) Antibody Janis, L. Scott, Robert M. Cassidy, and Lawrence F. Kromer. "Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum." The Journal of neuroscience 19.12 (1999): 4962-4971. Rat IHC 59 10366629
24216 Opioid Receptor-Mu (MOR) Antibody Ji, Yaping, Anne Z. Murphy, and Richard J. Traub. "Estrogen modulation of morphine analgesia of visceral pain in female rats is supraspinally and peripherally mediated." The Journal of Pain 8.6 (2007): 494-502. Rat 35 18550290
24216 Opioid Receptor-Mu (MOR) Antibody Melone, M., et al. "Etorphine increases the number of ?-opioid receptor-positive cells in the cerebral cortex." Neuroscience 100.3 (2000): 439-443. 3 11098106
24216 Opioid Receptor-Mu (MOR) Antibody Ko, Shanelle W., et al. "Evidence for a role of CaMKIV in the development of opioid analgesic tolerance." European Journal of Neuroscience 23.8 (2006): 2158-2168. Starling 16 16630062
24216 Opioid Receptor-Mu (MOR) Antibody Van Bockstaele, Elisabeth J., et al. "Evidence for coexistence of enkephalin and glutamate in axon terminals and cellular sites for functional interactions of their receptors in the rat locus coeruleus." Journal of Comparative Neurology 417.1 (2000): 103-114. Rat ICC 41 10660891
24216 Opioid Receptor-Mu (MOR) Antibody Ena, Sabrina L., et al. "FACS array profiling identifies ecto-5? nucleotidase as a striatopallidal neuron-specific gene involved in striatal-dependent learning." The Journal of neuroscience 33.20 (2013): 8794-8809. Mouse IF 2 23678122
24216 Opioid Receptor-Mu (MOR) Antibody Glickstein, Sara B., and Claudia Schmauss. "Focused motor stereotypies do not require enhanced activation of neurons in striosomes." Journal of Comparative Neurology 469.2 (2004): 227-238. Mouse 18 14694536
24216 Opioid Receptor-Mu (MOR) Antibody Breuer, O., et al. "Functional architecture of the mammalian striatum: mouse vascular and striosome organization and their anatomic relationships." Neuroscience letters 385.3 (2005): 198-203. Mouse 7 15970379
24216 Opioid Receptor-Mu (MOR) Antibody Hawes, Jessica J., Roopashree Narasimhaiah, and Marina R. Picciotto. "Galanin attenuates cyclic AMP regulatory element?binding protein (CREB) phosphorylation induced by chronic morphine and naloxone challenge in Cath. a cells and primary striatal cultures." Journal of neurochemistry 96.4 (2006): 1160-1168. Mouse 16 16417577
24216 Opioid Receptor-Mu (MOR) Antibody Richardson, Kimberlei A., and Philip J. Gatti. "Genioglossal hypoglossal muscle motoneurons are contacted by nerve terminals containing delta opioid receptor but not mu opioid receptor-like immunoreactivity in the cat: a dual labeling electron microscopic study." Brain research 1032.1 (2005): 23-29. Cat ICC 6 15680937
24216 Opioid Receptor-Mu (MOR) Antibody Li, Jin-Lian, et al. "Immunocytochemical localization of?-opioid receptor in primary afferent neurons containing substance P or calcitonin gene-related peptide. A light and electron microscope study in the rat." Brain research 794.2 (1998): 347-352. Rat IHC 64 9622672
24216 Opioid Receptor-Mu (MOR) Antibody J Biomed Sci. 2011 Jun 1;18:34. doi: 10.1186/1423-0127-18-34. Immunohistochemical localization of mu opioid receptor in the marginal division with comparison to patches in the neostriatum of the rat brain. Wang C1, Shu SY, Guo Z, Cai YF, Bao X, Zeng C, Wu B, Hu Z, Liu X. Rat IHC 21631922
24216 Opioid Receptor-Mu (MOR) Antibody Jaber, L., W. D. Swaim, and R. A. Dionne. "Immunohistochemical localization of ?-opioid receptors in human dental pulp." Journal of endodontics 29.2 (2003): 108-110. Human 31 12597708
24216 Opioid Receptor-Mu (MOR) Antibody Kawate, Toyoko, et al. "Immunohistochemical study of delta and mu opioid receptors on synaptic glomeruli with substance P-positive central terminals in chicken dorsal horn." Neuroscience research 53.3 (2005): 279-287. Chicken 6 16165241
24216 Opioid Receptor-Mu (MOR) Antibody Jabourian, Maritza, et al. "Impact of 6?hydroxydopamine lesions and cocaine exposure on Rat IHC 4 17425581
24216 Opioid Receptor-Mu (MOR) Antibody Skyers, P. S., et al. "Increased ?-opioid receptor labeling is found on inner molecular layer terminals of the dentate gyrus following seizures." Experimental neurology 179.2 (2003): 200-209. 25 12618127
24216 Opioid Receptor-Mu (MOR) Antibody Song, Bingbing, Wenling Chen, and Juan Carlos G. Marviz Rat 17 17555728
24216 Opioid Receptor-Mu (MOR) Antibody Chen W1, Song B, Marvizón JC, Neuropharmacology. 2008 May;54(6):944-53. doi: 10.1016/j.neuropharm.2008.02.002. Epub 2008 Feb 10. "Inhibition of opioid release in the rat spinal cord by alpha2C adrenergic receptors" Rat IHC 12 18343461
24216 Opioid Receptor-Mu (MOR) Antibody Neuroscience. 2007 Feb 9;144(3):889-97. Epub 2006 Dec 8. Integrins regulate opioid receptor signaling in trigeminal ganglion neurons. Berg KA1, Zardeneta G, Hargreaves KM, Clarke WP, Milam SB. Rat WB 17157995
24216 Opioid Receptor-Mu (MOR) Antibody Lee, Mao?Cheng, et al. "Internalization and trafficking of opioid receptor ligands in rat cortical neurons." Synapse 43.2 (2002): 102-111. Rat ICC 33 11754488
24216 Opioid Receptor-Mu (MOR) Antibody Van Bockstaele, E. J., and K. G. Commons. "Internalization of mu-opioid receptors produced by etorphine in the rat locus coeruleus." Neuroscience 108.3 (2001): 467-477. Rat 35 11738260
24216 Opioid Receptor-Mu (MOR) Antibody Neuroreport. 1999 Aug 2;10(11):2329-34. Internalization of mu-opioid receptors in rat spinal cord slices. Marvizón JC1, Grady EF, Waszak-McGee J, Mayer EA. Rat 43 10439458
24216 Opioid Receptor-Mu (MOR) Antibody Georgescu, Dan, et al. "Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal." The Journal of neuroscience 23.8 (2003): 3106-3111. Mouse IF 216 12716916
24216 Opioid Receptor-Mu (MOR) Antibody Kaufmann, Walter A., et al. "Kv4. 2 potassium channels segregate to extrasynaptic domains and influence intrasynaptic NMDA receptor NR2B subunit expression." Brain Structure and Function 218.5 (2013): 1115-1132. Rat, Mouse WB 1 22932868
24216 Opioid Receptor-Mu (MOR) Antibody PLoS One. 2010 Nov 10;5(11):e13861. doi: 10.1371/journal.pone.0013861. Levodopa-induced dyskinesia is associated with increased thyrotropin releasing hormone in the dorsal striatum of hemi-parkinsonian rats.Cantuti-Castelvetri I1, Hernandez LF, Keller-McGandy CE, Kett LR, Landy A, Hollingsworth ZR, Saka E, Crittenden JR, Nillni EA, Young AB, Standaert DG, Graybiel AM. Rat IHC parkinson 21085660
24216 Opioid Receptor-Mu (MOR) Antibody Minnis, J. G., et al. "Ligand-induced opioid receptor endocytosis and recycling in enteric neurons." Neuroscience 119.1 (2003): 33-42. IHC 48 12763066
24216 Opioid Receptor-Mu (MOR) Antibody Mandemakers, Wim, et al. "LRRK2 expression is enriched in the striosomal compartment of mouse striatum." Neurobiology of disease 48.3 (2012): 582-593. Mouse 8 22850484
24216 Opioid Receptor-Mu (MOR) Antibody Davies, B. L., et al. "Lung respiratory rhythm and pattern generation in the bullfrog: role of neurokinin-1 and ?-opioid receptors." Journal of Comparative Physiology B 179.5 (2009): 579-592. Tadpole, Frog IF 10 19184042
24216 Opioid Receptor-Mu (MOR) Antibody Pinard, C. R., F. Mascagni, and A. J. McDonald. "Medial prefrontal cortical innervation of the intercalated nuclear region of the amygdala." Neuroscience 205 (2012): 112-124. 20 22249157
24216 Opioid Receptor-Mu (MOR) Antibody Chuanga, Ronald Y. "Methadone induces CCR5 and promotes AIDS virus infection." FEBS Letters 519.173 (2002): 177. Human WB 0 12023039
24216 Opioid Receptor-Mu (MOR) Antibody Horner, Kristen A., Erika S. Noble, and Yamiece E. Gilbert. "Methamphetamine-induced stereotypy correlates negatively with patch-enhanced prodynorphin and< i< arc mRNA expression in the rat caudate putamen: The role of mu opioid receptor activation." Pharmacology Biochemistry and Behavior 95.4 (2010): 410-421. Rat 7 20298714
24216 Opioid Receptor-Mu (MOR) Antibody Gu, Yanping, Li-Yen Mae Huang, and Ya Xu. "Methods and materials for pain management." U.S. Patent No. 7,807,651. 5 Oct. 2010. 0 not found
24216 Opioid Receptor-Mu (MOR) Antibody Spike, R. C., et al. "MOR-1 immunoreactive neurons in the dorsal horn of the rat spinal cord: evidence for nonsynaptic innervation by substance P?containing primary afferents and for selective activation by noxious thermal stimuli." European Journal of Neuroscience 15.8 (2002): 1306-1316. Rat 52 11994125
24216 Opioid Receptor-Mu (MOR) Antibody Haberstock-Debic, Helena, et al. "Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons." The Journal of neuroscience 23.10 (2003): 4324-4332. Rat ICC 110 12764121
24216 Opioid Receptor-Mu (MOR) Antibody Haberstock-Debic, Helena, et al. "Morphine promotes rapid, arrestin-dependent endocytosis of ?-opioid receptors in striatal neurons." The Journal of neuroscience 25.34 (2005): 7847-7857. Rat IHC 106 16120787
24216 Opioid Receptor-Mu (MOR) Antibody Jaremko, Kellie M., et al. "Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons." Progress in Neuro-Psychopharmacology and Biological Psychiatry 50 (2014): 53-65. Rat IHC 0 24333843
24216 Opioid Receptor-Mu (MOR) Antibody van den Munckhof, Pepijn, et al. "Morphogenesis of rodent neostriatum following early developmental dopamine depletion." The Basal Ganglia IX. Springer New York, 2009. 399-410. 1 not found
24216 Opioid Receptor-Mu (MOR) Antibody Wang, Qing-Ping, et al. "Morphological evidence of endomorphin as an agonist for the mu-opioid receptor in the rat spinal cord." Neuroscience letters 341.2 (2003): 107-110. Rat 24 12686377
24216 Opioid Receptor-Mu (MOR) Antibody Philippe, David, et al. "Mu opioid receptor expression is increased in inflammatory bowel diseases: implications for homeostatic intestinal inflammation." Gut 55.6 (2006): 815-823. Human IHC 42 16299031
24216 Opioid Receptor-Mu (MOR) Antibody Drake, Carrie T., and Teresa A. Milner. "Mu opioid receptors are in somatodendritic and axonal compartments of GABAergic neurons in rat hippocampal formation." Brain research 849.1 (1999): 203-215. Rat 87 10592303
24216 Opioid Receptor-Mu (MOR) Antibody Lonergan, Tina, et al. "Mu opioid receptors in rat ventral medulla: effects of endomorphin-1 on phrenic nerve activity." Respiratory physiology & neurobiology 138.2 (2003): 165-178. Rat 27 14609508
24216 Opioid Receptor-Mu (MOR) Antibody Jaferi, Azra, and Virginia M. Pickel. "Mu-opioid and corticotropin-releasing-factor receptors show largely postsynaptic co-expression, and separate presynaptic distributions, in the mouse central amygdala and bed nucleus of the stria terminalis." Neuroscience 159.2 (2009): 526-539. Mouse 24 19166913
24216 Opioid Receptor-Mu (MOR) Antibody Ho, Anthony, et al. "Neurochemically distinct classes of myenteric neurons express the ??opioid receptor in the guinea pig ileum." Journal of Comparative Neurology 458.4 (2003): 404-411. Guinea Pig IF 27 12619074
24216 Opioid Receptor-Mu (MOR) Antibody Song, B., and J. C. G. Marvizon. "N-methyl-d-aspartate receptors and large conductance calcium-sensitive potassium channels inhibit the release of opioid peptides that induce ?-opioid receptor internalization in the rat spinal cord." Neuroscience 136.2 (2005): 549-562. 14 not found
24216 Opioid Receptor-Mu (MOR) Antibody Patierno, Simona, et al. " N -Methyl-d-Aspartate Receptors Mediate Endogenous Opioid Release in Enteric Neurons After Abdominal Surgery." Gastroenterology 128.7 (2005): 2009-2019. Guinea Pig 16 15940633
24216 Opioid Receptor-Mu (MOR) Antibody Lao, Lijun, et al. "Noxious mechanical stimulation evokes the segmental release of opioid peptides that induce ?-opioid receptor internalization in the presence of peptidase inhibitors." Brain research 1197 (2008): 85-93. Rat IHC 14 18207137
24216 Opioid Receptor-Mu (MOR) Antibody PLoS One. 2011 Jan 28;6(1):e16619. doi: 10.1371/journal.pone.0016619.Nr4a1-eGFP is a marker of striosome-matrix architecture, development and activity in the extended striatum. Davis MI1, Puhl HL 3rd. Mouse IF 21305052
24216 Opioid Receptor-Mu (MOR) Antibody Schmidt, P., et al. "Numerical density of opioidreceptor expressing neurons in the frontal cortex of drug related fatalities." Forensic science international 115.3 (2001): 219-229. 20 11074177
24216 Opioid Receptor-Mu (MOR) Antibody Reyes, B. A. S., et al. "Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons." Experimental neurology 233.1 (2012): 205-213. Rat 7 22001156
24216 Opioid Receptor-Mu (MOR) Antibody Li, Cheng-Shu, Barry J. Davis, and David V. Smith. "Opioid modulation of taste responses in the nucleus of the solitary tract." Brain research 965.1 (2003): 21-34. IHC 38 12591116
24216 Opioid Receptor-Mu (MOR) Antibody Lawhorn, Collene, Diane M. Smith, and Lucy L. Brown. "Partial ablation of mu-opioid receptor rich striosomes produces deficits on a motor-skill learning task." Neuroscience 163.1 (2009): 109-119. Mouse IHC 9 19463902
24216 Opioid Receptor-Mu (MOR) Antibody J Neurosci. 2003 Mar 1;23(5):1847-58. Peptidases prevent mu-opioid receptor internalization in dorsal horn neurons by endogenously released opioids. Song B1, Marvizón JC. Rat IF 45 12629189
24216 Opioid Receptor-Mu (MOR) Antibody EMBO J. 2005 Sep 21;24(18):3235-46. Epub 2005 Sep 1. Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis.Macé G1, Miaczynska M, Zerial M, Nebreda AR. Mouse IF 98 16138080
24216 Opioid Receptor-Mu (MOR) Antibody J Neurophysiol. 2011 Jun;105(6):3054-66. doi: 10.1152/jn.00136.2011. Epub 2011 Apr 6. Physiological identification and infralimbic responsiveness of rat intercalated amygdala neurons. Amir A1, Amano T, Pare D. Rat IF 21471396
24216 Opioid Receptor-Mu (MOR) Antibody Wang, H., V. C. Cuzon, and V. M. Pickel. "Postnatal development of ?-opioid receptors in the rat caudate-putamen nucleus parallels asymmetric synapse formation." Neuroscience 118.3 (2003): 695-708. Rat 34 12710977
24216 Opioid Receptor-Mu (MOR) Antibody J Neurosci. 2000 Aug 15;20(16):6249-55. Transduction sites of vagal mechanoreceptors in the guinea pig esophagus. Zagorodnyuk VP1, Brookes SJ. Rat IF 11102461
24216 Opioid Receptor-Mu (MOR) Antibody Wang, Hong, and Virginia M. Pickel. "Preferential cytoplasmic localization of ?-opioid receptors in rat striatal patches: comparison with plasmalemmal ?-opioid receptors." The Journal of Neuroscience 21.9 (2001): 3242-3250. Rat ICC 67 11312309
24216 Opioid Receptor-Mu (MOR) Antibody Commons, Kathryn G., et al. "Presynaptic and postsynaptic relations of ??opioid receptors to ??aminobutyric acid?immunoreactive and medullary?projecting periaqueductal gray neurons." Journal of Comparative Neurology 419.4 (2000): 532-542. Rat 44 10742719
24216 Opioid Receptor-Mu (MOR) Antibody Berg KA1, Patwardhan AM, Sanchez TA, Silva YM, Hargreaves KM, Clarke WP., J Pharmacol Exp Ther. 2007 Jun;321(3):839-47. Epub 2007 Mar 8."Rapid modulation of micro-opioid receptor signaling in primary sensory neurons" Rat IHC 36 17347322
24216 Opioid Receptor-Mu (MOR) Antibody Horner, Kristen A., and Kristen A. Keefe. "Regulation of psychostimulant-induced preprodynorphin, c-fos and zif/268 messenger RNA expression in the rat dorsal striatum by mu opioid receptor blockade." European journal of pharmacology 532.1 (2006): 61-73. Rat 16 16443216
24216 Opioid Receptor-Mu (MOR) Antibody Neuroscience. 2007 May 25;146(3):1346-54. Epub 2007 Mar 26. Role of peripheral mu-opioid receptors in inflammatory orofacial muscle pain. Nũnéz S1, Lee JS, Zhang Y, Bai G, Ro JY. Rat 22 17379421
24216 Opioid Receptor-Mu (MOR) Antibody Balfour, Margaret E., Lei Yu, and Lique M. Coolen. "Sexual behavior and sex-associated environmental cues activate the mesolimbic system in male rats." Neuropsychopharmacology 29.4 (2004): 718-730. Rat ICC 121 14694350
24216 Opioid Receptor-Mu (MOR) Antibody Desreumaux, Pierre, and Didier Carcano. "Strain of Lactobacillus Acidophilus Having Analgesic Properties in the Gastrointestinal System." U.S. Patent Application 11/661,534. 0 not found
24216 Opioid Receptor-Mu (MOR) Antibody Colelli V1, Fiorenza MT, Conversi D, Orsini C, Cabib S, Genes Brain Behav. 2010 Oct;9(7):703-11. doi: 10.1111/j.1601-183X. 2010.00604.x. Epub 2010 Jul 5. "Strain-specific proportion of the two isoforms of the dopamine D2 receptor in the mouse striatum: associated neural and behavioral phenotypes" Mouse 9 20546314
24216 Opioid Receptor-Mu (MOR) Antibody Massart, Renaud, et al. "Striatal GPR88 expression is confined to the whole projection neuron population and is regulated by dopaminergic and glutamatergic afferents." European Journal of Neuroscience 30.3 (2009): 397-414. Rat 16 19656174
24216 Opioid Receptor-Mu (MOR) Antibody Lawhorn, Collene, Diane M. Smith, and Lucy L. Brown. "Striosome-matrix pathology and motor deficits in the YAC128 mouse model of Huntington's disease." Neurobiology of disease 32.3 (2008): 471-478. Mouse huntington 11 18809498
24216 Opioid Receptor-Mu (MOR) Antibody Wiley, Ronald G., and Douglas A. Lappi. "Targeted toxins in pain." Advanced drug delivery reviews 55.8 (2003): 1043-1054. 31 12935943
24216 Opioid Receptor-Mu (MOR) Antibody Wirtshafter, David, and Catherine V. Osborn. "The distribution of m4 muscarinic acetylcholine receptors in the islands of Calleja and striatum of rats and cynomolgus monkeys." Journal of chemical neuroanatomy 28.3 (2004): 107-116. Monkey, Rat 7 15482898
24216 Opioid Receptor-Mu (MOR) Antibody Chen, Jun, et al. "The locus coeruleus of the Japanese monkey (Macaca fuscata) does not express?-opioid receptor-like immunoreactivity." Brain research 755.2 (1997): 326-330. Monkey 2 9175900
24216 Opioid Receptor-Mu (MOR) Antibody Bereiter, D. A., D. F. Bereiter, and H. Hirata. "Topical cannabinoid agonist, WIN55, 212-2, reduces cornea-evoked trigeminal brainstem activity in the rat." Pain 99.3 (2002): 547-556. Rat 21 12406531
24216 Opioid Receptor-Mu (MOR) Antibody BOLIVIA, NEWBORNS IN. "TORRICO AND OTHERS CONSEQUENCES OF MATERNAL T. CRUZI INFECTION." Human 0 14993634
24216 Opioid Receptor-Mu (MOR) Antibody Bigliardi, Paul L., et al. "Treatment of pruritus with topically applied opiate receptor antagonist." Journal of the American Academy of Dermatology 56.6 (2007): 979-988. IHC 63 17320241
24216 Opioid Receptor-Mu (MOR) Antibody Milner, Teresa A., and Carrie T. Drake. "Ultrastructural evidence for presynaptic ? opioid receptor modulation of synaptic plasticity in NMDA-receptor-containing dendrites in the dentate gyrus." Brain research bulletin 54.2 (2001): 131-140. 27 11275401
24216 Opioid Receptor-Mu (MOR) Antibody J Physiol. 2006 Sep 15;575(Pt 3):761-76. Epub 2006 Jul 6. Vagal afferent control of opioidergic effects in rat brainstem circuits. Browning KN1, Zheng Z, Gettys TW, Travagli RA. Rat IF 16825311
24216 Opioid Receptor-Mu (MOR) Antibody Oscilowski, Z., et al. "Zur Zelldichte IHC 0 not found
24216 Opioid Receptor-Mu (MOR) Antibody Chen W1, McRoberts JA1, Marvizón JC2, Neuroscience. 2014 May 16;267:67-82. doi: 10.1016/j.neuroscience.2014.02.023. Epub 2014 Feb 26. "μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain" Rat IHC 0 24583035
24216 Opioid Receptor-Mu (MOR) Antibody Scavone, Jillian L., and Elisabeth J. Van Bockstaele. "??Opioid Receptor Redistribution in the Locus Coeruleus Upon Precipitation of Withdrawal in Opiate?Dependent Rats." The Anatomical Record 292.3 (2009): 401-411. Rat IF 6 19248160
24216 Opioid Receptor-Mu (MOR) Antibody J Comp Neurol. 2001 Apr 23;433(1):34-47. Mu-opioid receptors are present in functionally identified sympathoexcitatory neurons in the rat rostral ventrolateral medulla.Aicher SA1, Schreihofer AM, Kraus JA, Sharma S, Milner TA, Guyenet PG. Rat 32 11283947
24216 Opioid Receptor-Mu (MOR) Antibody Ruiz, Marta, et al. "Abnormalities of motor function, transcription and cerebellar structure in mouse models of THAP1 dystonia." Human Molecular Genetics (2015): ddv384. Mouse 0 not defined
24216 Opioid Receptor-Mu (MOR) Antibody Huerta-Ocampo, Icnelia, Juan Mena-Segovia, and J. Paul Bolam. "Convergence of cortical and thalamic input to direct and indirect pathway medium spiny neurons in the striatum." Brain Structure and Function 219.5 (2014): 1787-1800. Mouse IF 15 23832596
24216 Opioid Receptor-Mu (MOR) Antibody Xu, Pingwen, et al. "Estrogen receptor–α in medial amygdala neurons regulates body weight." The Journal of clinical investigation 125.7 (2015): 2861. Mouse Obesity 2 26098212
24216 Opioid Receptor-Mu (MOR) Antibody Zhang, J., J. F. Muller, and A. J. McDonald. "Mu opioid receptor localization in the basolateral amygdala: An ultrastructural analysis." Neuroscience 303 (2015): 352-363. 0 not defined
24216 Opioid Receptor-Mu (MOR) Antibody Bai, Xiaofeng, et al. "Sex Differences in Peripheral Mu-Opioid Receptor Mediated Analgesia in Rat Orofacial Persistent Pain Model." PloS one 10.3 (2015). Rat Pain 0 25807259
24216 Opioid Receptor-Mu (MOR) Antibody Desreumaux, Pierre, and Didier Carcano. "Strain of lactobacillus acidophilus having analgesic properties in the gastrointestinal system." U.S. Patent Application 14/506,065. 0 not found
24216 Opioid Receptor-Mu (MOR) Antibody Chen, Wenling, James A. McRoberts, and Juan Carlos G. Marvizón. "μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain." Neuroscience 267 (2014): 67-82. Rat Pain 6 not defined

Q & A Wall

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I pretend to separate cellular membranes from citoplasm and make WB by separate in order to semiquantify receptors in membranes and in citoplasm, because I assume that if receptors are in citoplams is because they were endocyted after being activated. So, is this assumtion true?
Question By Eli

We currently do not carry an antibody to the phosphorylated mu opioid receptor. Also, it is best practice to run an antibody on both the membrane and cytosolic fractions to get an idea of the antigen's expression in your experimental conditions.

Answer By Andy K. on 2015-11-03 11:35:59

We are using Mu Opioid Receptor antibody (#24216) for Western Blotting and need to know with what species it might cross react. In addition, does it detect other receptors (such as delta or kappa)?
Question By Nancy

Our MOR-1 aby is raised against the sequence 384-398 of the cloned rat MOR-1. The sequence is 100% homolgous to rat, pig, mouse, human and macac (monkey). The MW based on amino acids of rat MOR-1 is around 44-45 kD, but the protein is heavily glycosylated. Another researcher used our aby and saw around 50-52 kD. The antibody was characterized as specific to MOR-1 by Bob Elde, U of M and does not x-react with delta or kappa. We are sure about the MOR splice variants.


Answer By Jodi on 2015-03-04 11:57:58

I have purchased antibody for the Mu Opioid receptor, Cat# 24216. You present storage recommendations with dilution in PBS or TBS, no higher than 1:10. I have 2 questions; 1: Could we not reconstitute the the vial in 100 ul of PBS instead of dH2O to prevent further dilutions of the antibody? 2: I am assuming that a dilution no higher than 1:10 means that I could reconstitute in 100 ul dH2O and then add 100 ul of PBS?
Question By Nigel

1. We do not have any supporting data for reconstituting the Mu Opioid receptor directly with PBS, so we are not certain if that would cause any problems with the antibody. You could, however, reconstitute it with 100 uL of dH2O and then dilute it with another 100 uL of double strength PBS. This would then leave you with the correct concentration of the PBS and not dilute out the antibody.

2. Yes, you could do a 1:2 dilution of the antibody for storage.

Answer By Jodi on 2005-10-24 11:47:41

MSDS

This product contains the preservative sodium azide. The concentration percent of the sodium azide is ≤ .09%. Although this hazardous substance is a concentration below that required for the preparation of a Material Safety Data Sheet, we created a standard MSDS for your records.

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