Neuropeptide Y Y1 Receptor Antibody

Neuropeptide Y Y1 Receptor Antibody
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Price: $375.00
Product ID : 24506

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Description

The ImmunoStar Neuropeptide Y Y1 Receptor was quality control tested using standard immunohistochemical methods. The antiserum demonstrates strongly positive labeling of rat cortex, arcuate and hippocampus using indirect immunofluorescent and biotin/avidin-HRP techniques. Recommended primary dilutions are 1/500 - 1/1000 in PBS - Bn/Av-HRP detection.

The antibody was characterized by immunohistochemistry and Western blot. Western blot showed one immunoreactive band of 40 kD and a single high molecular weight band, presumably a precursor molecule.

Preincubation of the antibody with an excess of the synthetic peptide blocked staining. Immunohistochemical staining of rat brain correlates well with Northern analysis, in situ hybridization and receptor autoradiography. BlastP database sequence homology searches confirmed that this sequence is unique to rat, mouse and human NPY Y1 receptors.

Photo Description: IHC image of the rat cortex staining for the neuropeptide Y Y1 recptor. The tissue was fixed with 4% formaldehyde/0.05% glutaraldehyde in 0.1 M phosphate buffer, before being removed and prepared for vibratome sectioning. Floating sections were incubated at RT in 10% goat serum in PBS, before standard IHC procedure. Primary antibody was incubated at 1:5000 for 48 hours, goat anti-rabbit secondary was subsequently added for 1 hour after washing with PBS. Light microscopy staining was achieved with standard biotin-streptavidin/HRP procedure and DAB chromogen. 

Host
: Rabbit

Quantity / Volume:  100 µL

State: Liquid

Reacts With: Hamster, Human, Mouse, Rat

Availability: In Stock

Alternate Names:  Neuropeptide Y receptor 1; NPY receptor 1; NPYR; NPYY1; NPY1-R; Neuropeptide Y receptor type 1; FC5; NPYR1, neuropeptide Y1 receptor, anti-NPYY1

Gene Symbol / ID, Accession #:  neuropeptide Y receptor Y1, anti-NPYY1

RRID:  AB_572257

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Publications

PROD # ANTIBODY CITATION SPECIES REACTIVITY APPL METHOD RESEARCH AREA # CITED BY PUBMED ID
24506 Neuropeptide Y Y1 Receptor Antibody Dubois, Christophe J., et al. "Activation of NPY type 5 receptors induces a long-lasting increase in spontaneous GABA release from cerebellar inhibitory interneurons." Journal of neurophysiology 107.6 (2012): 1655. Mouse ICC 2 22190627
24506 Neuropeptide Y Y1 Receptor Antibody Dailey MJ1, Bartness TJ, Brain Res. 2010 Apr 6;1323:94-108. doi: 2010.01.078. Epub 2010 Feb 4."Arcuate nucleus destruction does not block food deprivation-induced increases in food foraging and hoarding" Hamster IHC aging 20138163
24506 Neuropeptide Y Y1 Receptor Antibody Khan, Javed, and Marc Ladanyi. "Classification of Pediatric Tumors Using DNA Microarrays." Expression Profiling of Human Tumors. Humana Press, 2003. 295-304. DNA 0 not found
24506 Neuropeptide Y Y1 Receptor Antibody Killough, S. A., F. T. Lundy, and C. R. Irwin. "Dental pulp fibroblasts express neuropeptide Y Y1 receptor but not neuropeptide Y." International endodontic journal 43.10 (2010): 835-842. Human 3 20636351
24506 Neuropeptide Y Y1 Receptor Antibody Mills, Richard H., Richard K. Sohn, and Paul E. Micevych. "Estrogen-induced ?-opioid receptor internalization in the medial preoptic nucleus is mediated via neuropeptide Y-Y1 receptor activation in the arcuate nucleus of female rats." The Journal of neuroscience 24.4 (2004): 947-955. Rat ICC 72 14749439
24506 Neuropeptide Y Y1 Receptor Antibody Regul Pept. 2005 Jul 15;129(1-3):119-24. Functional expression of neuropeptide Y receptors in human neuroblastoma cells. Li AJ1, Ritter S. Human 7 15927706
24506 Neuropeptide Y Y1 Receptor Antibody Endocrinology. 2006 Sep;147(9):4122-31. Epub 2006 May 25.Influence of dehydration on the expression of neuropeptide Y Y1 receptors in hypothalamic magnocellular neurons. Urban JH1, Leitermann RJ, DeJoseph MR, Somponpun SJ, Wolak ML, Sladek CD. Rat IF 16728491
24506 Neuropeptide Y Y1 Receptor Antibody Dimitrov, Eugene L., et al. "Involvement of neuropeptide Y Y1 receptors in the regulation of neuroendocrine corticotropin-releasing hormone neuronal activity." Endocrinology 148.8 (2007): 3666-3673. Rat IF 27 17463058
24506 Neuropeptide Y Y1 Receptor Antibody Pain. 2007 May;129(1-2):143-54. Epub 2006 Dec 6. Nerve injury-induced tactile allodynia is present in the absence of FOS labeling in retrogradely labeled post-synaptic dorsal column neurons. Zhang ET1, Ossipov MH, Zhang DQ, Lai J, Porreca F. Rat IF 17156921
24506 Neuropeptide Y Y1 Receptor Antibody Klenke, Ulrike, Stephanie Constantin, and Susan Wray. "Neuropeptide Y directly inhibits neuronal activity in a subpopulation of gonadotropin-releasing hormone-1 neurons via Y1 receptors." Endocrinology 151.6 (2010): 2736-2746. Mouse IF 26 20351316
24506 Neuropeptide Y Y1 Receptor Antibody Hiruma, Hiromi, et al. "Neuropeptide Y inhibits axonal transport of particles in neurites of cultured adult mouse dorsal root ganglion cells." The Journal of physiology 543.1 (2002): 85-97. Mouse ICC 7 12181283
24506 Neuropeptide Y Y1 Receptor Antibody Gibbs JL1, Diogenes A, Hargreaves KM, Br J Pharmacol. 2007 Jan;150(1):72-9. Epub 2006 Dec 4. "Neuropeptide Y modulates effects of bradykinin and prostaglandin E2 on trigeminal nociceptors via activation of the Y1 and Y2 receptors" Rat IF 17143304
24506 Neuropeptide Y Y1 Receptor Antibody El Karim, I. A., et al. "Neuropeptide Y Y1 receptor in human dental pulp cells of noncarious and carious teeth." International endodontic journal 41.10 (2008): 850-855. Human 14 18699789

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MSDS

This product contains the preservative sodium azide. The concentration percent of the sodium azide is ≤ .09%. Although this hazardous substance is a concentration below that required for the preparation of a Material Safety Data Sheet, we created a standard MSDS for your records.

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