mGluR1 alpha (Metabotropic Glutamate Receptor) Antibody - No longer available

mGluR1 alpha (Metabotropic Glutamate Receptor) Antibody - No longer available
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Product ID : 24426

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Description

The mGluR1a Antibody is no longer available from ImmunoStar.  To purchase this antibody, please refer to PhosphoSolutions. 


The antibody has significant biotin-avidin HRP staining at a 1/300 - 1/500 dilution in rat thalamus, hippocampus and cortex. Optimal dilution will vary depending upon fixation, labeling technique and/or detection system; therefore, a dilution series is recommended.  The antibody is specific for the ~125k monomer and the ~250k mGluR1a dimer in Western blots of rat brain extracts.  Immunolabeling for mGluR1a is completely abolished by preadsorption with synthetic rat mGluR1a (1116-1130) at 5 µg per mL of diluted antibody.  Note:  If needed, low levels of glutaraldehyde (0.1 - 0.3%) may be used   in conjunction with paraformaldehyde.

Photo Description: IHC image of neurons staining for the mGluR1 alpha in the rat hippocampus (above) and western blot showing specificity of the antibody at 132 kDa (below). For IHC, the tissue was fixed with 4% formaldehyde in 0.1 M phosphate buffer, before being removed and prepared for vibratome sectioning. Floating sections were incubated at RT in 10% goat serum in PBS, before standard IHC procedure. Primary antibody was incubated at 1:500 for 48 hours, goat anti-rabbit secondary was subsequently added for 1 hour after washing with PBS. Light microscopy staining was achieved with standard biotin-streptavidin/HRP procedure and DAB chromogen.

mGluR1 #24426

Host: Rabbit

Quantity / Volume:  100 µL

State: Liquid

Reacts With: Human, Mouse, Rat

Alternate Names:  mGluR1a; GRM1a; Gprc1a; Metabotropic glutamate receptor 1; mGluR1; G protein coupled receptor family C group 1 member A; glutamate receptor, metabotropic 1, anti-mGluR1a

Gene Symbol / ID, Accession #:  Grm1, 24414

RRID:  AB_572249

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Publications

PROD # ANTIBODY CITATION SPECIES REACTIVITY APPL METHOD RESEARCH AREA # CITED BY PUBMED ID
24426 mGluR1 alpha (Metabotropic Glutamate Receptor) Antibody Losonczy, Attila, et al. "Cell type dependence and variability in the short?term plasticity of EPSCs in identified mouse hippocampal interneurones." The Journal of physiology 542.1 (2002): 193-210. Mouse IHC 82 12096061
24426 mGluR1 alpha (Metabotropic Glutamate Receptor) Antibody Tukker, John J., et al. "Cell type-specific tuning of hippocampal interneuron firing during gamma oscillations in vivo." The journal of neuroscience 27.31 (2007): 8184-8189. Rat IF 142 17670965
24426 mGluR1 alpha (Metabotropic Glutamate Receptor) Antibody Alvarez, Francisco J., et al. "Differential distribution of metabotropic glutamate receptors 1a, 1b, and 5 in the rat spinal cord." Journal of Comparative Neurology 422.3 (2000): 464-487. Rat IHC 115 10861520
24426 mGluR1 alpha (Metabotropic Glutamate Receptor) Antibody Ferraguti, Francesco, Luca Crepaldi, and Ferdinando Nicoletti. "Metabotropic glutamate 1 receptor: current concepts and perspectives." Pharmacological reviews 60.4 (2008): 536-581. Mouse 97 19112153
24426 mGluR1 alpha (Metabotropic Glutamate Receptor) Antibody Namkoong, Jin, et al. "Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma." Cancer research 67.5 (2007): 2298-2305. Human 77 17332361
24426 mGluR1 alpha (Metabotropic Glutamate Receptor) Antibody Ferraguti, Francesco, et al. "Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus." The Journal of neuroscience 25.45 (2005): 10520-10536. Rat ICC 57 16280590
24426 mGluR1 alpha (Metabotropic Glutamate Receptor) Antibody Karim, Farzana, Chia-Chuan Wang, and Robert W. Gereau. "Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice." The Journal of Neuroscience 21.11 (2001): 3771-3779. Mouse ICC 302 11356865
24426 mGluR1 alpha (Metabotropic Glutamate Receptor) Antibody Dobi, Alice, et al. "Neural substrates for the distinct effects of presynaptic group III metabotropic glutamate receptors on extinction of contextual fear conditioning in mice." Neuropharmacology 66 (2013): 274-289. Mouse ICC 4 22643400
24426 mGluR1 alpha (Metabotropic Glutamate Receptor) Antibody Bhave, G., et al. "Peripheral group I metabotropic glutamate receptors modulate nociception in mice." Nature neuroscience 4.4 (2001): 417-423. Mouse IHC 225 11276233
24426 mGluR1 alpha (Metabotropic Glutamate Receptor) Antibody Neves, Guilherme, et al. "The LIM homeodomain protein Lhx6 regulates maturation of interneurons and network excitability in the mammalian cortex." Cerebral Cortex 23.8 (2013): 1811-1823. Mouse IF 6 22710612
24426 mGluR1 alpha (Metabotropic Glutamate Receptor) Antibody Crepaldi, Luca, et al. "Transcriptional activators and repressors for the neuron-specific expression of a metabotropic glutamate receptor." Journal of Biological Chemistry 282.24 (2007): 17877-17889. Human, Mouse IF Transcription Factor 11 17430891
24426 mGluR1 alpha (Metabotropic Glutamate Receptor) Antibody Notenboom, Robbert GE, et al. "Up-regulation of hippocampal metabotropic glutamate receptor 5 in temporal lobe epilepsy patients." Brain 129.1 (2006): 96-107. Rat 59 16311265

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MSDS

This product contains the preservative sodium azide. The concentration percent of the sodium azide is ≤ .09%. Although this hazardous substance is a concentration below that required for the preparation of a Material Safety Data Sheet, we created a standard MSDS for your records.

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