CGRP (Calcitonin Gene Related Peptide) Antibody

CGRP (Calcitonin Gene Related Peptide) Antibody
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Price: $275.00
Product ID : 24112

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Description

The antibody has a proven and strong Biotin-Streptadvidin/HRP staining at a 1/2000-1/4000 dilution in rat amygdala, and spinal cord.

The specificity of the antiserum was evaluated by soluble pre-adsorption with the peptides in question at a final concentration of 10-5M. CGRP immunolabeling was completely abolished by pre-adsorption with rat α -CGRP and partially eliminated by pre-adsorption with rat Ÿ -CGRP. Pre-adsorption with the following peptides resulted in no loss of immunostaining: rat amylin, rat adrenomedulin, calcitonin, neurotensin, somatostatin, substance P, leucine enkephalin, methionine enkephalin, VIP, CCK-8, vasopressin and neuropeptide Y.

Photo Description: IHC image of the dorsal horn of the rat spinal cord staining for CGRP (above) and low magnification image of a coronal spinal cord section staining for CGRP (below). The tissue was fixed with 4% formaldehyde in phosphate buffer, before being removed and prepared for frozen sectioning. Sections were incubated at RT in 10% goat serum in PBS, before standard IHC procedure. Primary antibody was incubated at 1:4000 for 48 hours, goat anti-rabbit secondary was subsequently added for 1 hour after washing with PBS. Light microscopy staining was achieved with standard biotin-streptavidin/HRP procedure and DAB chromogen.

CGRP spinal cord #24112

Host: Rabbit

Quantity / Volume:  100 µL

State: Lyophilized Whole Serum

Reacts With: Bullfrog, Cat, Dog, Hamster, Human, Mouse, Mudpuppy (Necturus Maculosus), Ovine (Sheep), Pig, Platypus, Ram (Sheep), Rat

Availability: In Stock

Alternate Names:  anti-CGRP

RRID:  AB_572217

Immunogen: rat alpha-CGRP

Gene Symbol: Calca

Entrez Gene ID: 24241

NCBI Gene Aliases: CAL6,CGRP,Cal1,Calc,RATCAL6,calcitoni

Reviews

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Reviewed by sherrywjj
04/28/2015 - 06:03:44 PM
Works great

This antibody works great on my tissue. With 1:500 to 1:1000 dilution, the result is superb!

Publications

PROD # ANTIBODY CITATION SPECIES REACTIVITY APPL METHOD RESEARCH AREA # CITED BY PUBMED ID
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Hodgetts, Stuart I., Paul J. Simmons, and Giles W. Plant. "A comparison of the behavioral and anatomical outcomes in sub-acute and chronic spinal cord injury models following treatment with human mesenchymal precursor cell transplantation and recombinant decorin." Experimental neurology 248 (2013): 343-359. Human 1 23867131
24112 CGRP (Calcitonin Gene Related Peptide) Antibody J Neurosci. 2009 Oct 28;29(43):13473-83. doi: 10.1523/JNEUROSCI.1822-09.2009. A key role for gp130 expressed on peripheral sensory nerves in pathological pain. Andratsch M1, Mair N, Constantin CE, Scherbakov N, Benetti C, Quarta S, Vogl C, Sailer CA, Uceyler N, Brockhaus J, Martini R, Sommer C, Zeilhofer HU, Müller W, Kuner R, Davis JB, Rose-John S, Kress M. Mouse IF 19864560
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Tsai, Eve C., et al. "A novel method for simultaneous anterograde and retrograde labeling of spinal cord motor tracts in the same animal." Journal of Histochemistry & Cytochemistry 49.9 (2001): 1111-1122. Rat IHC, IF 32 11511680
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Fowler, Marcie, et al. "A rat model of full thickness thermal injury characterized by thermal hyperalgesia, mechanical allodynia, pronociceptive peptide release and tramadol analgesia." Burns (2013). 0 24290856
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Ulrich-Lai, Yvonne M., et al. "ACTH inhibits the capsaicin-evoked release of CGRP from rat adrenal afferent nerves." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 280.1 (2001): R137-R142. Rat 7 11124144
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Ulrich-Lai, Yvonne M., and William C. Engeland. "Adrenal splanchnic innervation modulates adrenal cortical responses to dehydration stress in rats." Neuroendocrinology 76.2 (2002): 79-92. Rat IHC 61 12169769
24112 CGRP (Calcitonin Gene Related Peptide) Antibody J Neuroimmunol. 2007 Apr;185(1-2):64-74. Epub 2007 Mar 23. Anatomical evidence for enteric neuroimmune interactions in Peyer's patches. Vulchanova L1, Casey MA, Crabb GW, Kennedy WR, Brown DR. Pig IHC 17363074
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Brook, Gary A., et al. "Attempted endogenous tissue repair following experimental spinal cord injury in the rat: involvement of cell adhesion molecules L1 and NCAM?." European Journal of Neuroscience 12.9 (2000): 3224-3238. Rat IHC 51 10998106
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Brain Res. 2001 Mar 2;893(1-2):11-20. Axon terminals containing CGRP-immunoreactivity form synapses with CRF- and Met-enkephalin-immunopositive neurons in the laterodorsal division of the bed nucleus of the stria terminalis in the rat. Kozicz T1, Arimura A. Rat 17 11222987
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Jiang, Shi-Xu, et al. "Bcl-2 protein expression in lung cancer and close correlation with neuroendocrine differentiation." The American journal of pathology 148.3 (1996): 837. Human cancer 94 10229500
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Schicho, R., et al. "Capsaicin-sensitive extrinsic afferents are involved in acid?induced activation of distinct myenteric neurons in the rat stomach." Neurogastroenterology & Motility 15.1 (2003): 33-44. Rat 24 12588467
24112 CGRP (Calcitonin Gene Related Peptide) Antibody KEITH, INGEGERD M., et al. "Cell relationship in a Wistar rat model of spontaneous prostatitis." The Journal of urology 166.1 (2001): 323-328. Rat 30 11435894
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Orazzo, Catello, et al. "CGRP-like immunoreactivity in A11 dopamine neurons projecting to the spinal cord and a note on CGRP-CCK cross-reactivity." Brain research 600.1 (1993): 39-48. 42 8422589
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Kobayashi, Shigeru, et al. "Changes of calcitonin gene-related peptide in primary sensory neurons and their central branch after nerve root compression of the dog." Archives of physical medicine and rehabilitation 86.3 (2005): 527-533. Dog IHC 25 15759240
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Jacquin, Mark F., et al. "Cholecystokinin concentrations and peptide immunoreactivity in the intact and deafferented medullary dorsal horn of the rat." Journal of Comparative Neurology 326.1 (1992): 22-43. Rat 11 1479068
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Synapse. 2006 Sep 15;60(4):295-306. Choline acetyl transferase and neuropeptide immunoreactivities are colocalized in somata, but preferentially localized in distinct axon fibers and boutons of cat sympathetic preganglionic neurons.Sámano C1, Zetina ME, Marín MA, Cifuentes F, Morales MA. Cat IHC 9 16786529
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Barritt, A. W., et al. "Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury." The Journal of neuroscience 26.42 (2006): 10856-10867. Rat 210 17050723
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Gold, M. S., S. Dastmalchi, and J. D. Levine. "Co-expression of nociceptor properties in dorsal root ganglion neurons from the adult rat< i> in vitro." Neuroscience 71.1 (1996): 265-275. Rat 147 8834408
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Zhou, Li, et al. "Contribution of opioid receptors on primary afferent versus sympathetic neurons to peripheral opioid analgesia." Journal of Pharmacology and Experimental Therapeutics 286.2 (1998): 1000-1006. Rat ICC 115 9694961
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Kawatani, Masahito, Takashi Suzuki, and William C. de Groat. "Corticotropin releasing factor-like immunoreactivity in afferent projections to the sacral spinal cord of the cat." Journal of the autonomic nervous system 61.3 (1996): 218-226. Cat 18 8988478
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Hsu, Shu-Hao, et al. "Cutaneous and sympathetic denervation in neonatal rats with a mutation in the delta subunit of the cytosolic chaperonin-containing t-complex peptide-1 gene." Neurobiology of disease 16.2 (2004): 335-345. 5 15193290
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Nolano, Maria, et al. "Cutaneous innervation of the human face as assessed by skin biopsy." Journal of anatomy 222.2 (2013): 161-169. Human 6 23078075
24112 CGRP (Calcitonin Gene Related Peptide) Antibody El Bohy, Ashraf, and Carole C. Lamotte. "Deafferentation?induced changes in neuropeptides of the adult rat dorsal horn following pronase injection of the sciatic nerve." Journal of Comparative Neurology 336.4 (1993): 545-554. Rat 12 7503999
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Symons, Frank J., et al. "Degranulated mast cells in the skin of adults with self-injurious behavior and neurodevelopmental disorders." Brain, behavior, and immunity 23.3 (2009): 365-370. IHC 9 19084591
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Maier, Irin C., et al. "Differential effects of anti-Nogo-A antibody treatment and treadmill training in rats with incomplete spinal cord injury." Brain 132.6 (2009): 1426-1440. Rat IHC 75 19372269
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Hegarty, Deborah M., et al. "Differential localization of vesicular glutamate transporters and peptides in corneal afferents to trigeminal nucleus caudalis." Journal of Comparative Neurology 518.17 (2010): 3557-3569. Rat ICC 14 20593358
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Manger, Paul R., et al. "Distribution and putative function of autonomic nerve fibres in the bill skin of the platypus (Ornithorhynchus anatinus)." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 353.1372 (1998): 1159-1170. Platypus IHC 11 9720112
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Miyoshi, Masakazu, et al. "Distribution of epithelioid cells in the wall of the chicken aorta and their functional role as chemoreceptors." The Anatomical Record 242.3 (1995): 302-309. 4 7573977
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Takanami, Keiko, et al. "Distribution of gastrin releasing peptide in the rat trigeminal and spinal somatosensory systems." Journal of Comparative Neurology (2013). Rat IHC, IF 0 24254931
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Yip, Y. P., et al. "Ectopic sympathetic preganglionic neurons maintain proper connectivity in the reeler mutant mouse." Neuroscience 118.2 (2003): 439-450. Mouse 12 12699780
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Zhang, Q., et al. "Effects of neurotoxins and hindpaw inflammation on opioid receptor immunoreactivities in dorsal root ganglia." Neuroscience 85.1 (1998): 281-291. 81 9607719
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Sz?ke, E., et al. "Effects of raw soy diet on the rat parotid gland." Acta Alimentaria 38.2 (2009): 237-248. 2 not found
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Constantin, Cristina E., et al. "Endogenous tumor necrosis factor ? (TNF?) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model." The Journal of Neuroscience 28.19 (2008): 5072-5081. Mouse cancer 73 18463260
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Symons, Frank J., et al. "Evidence of altered epidermal nerve fiber morphology in adults with self-injurious behavior and neurodevelopmental disorders." Pain 134.1 (2008): 232-237. Human 9 17850969
24112 CGRP (Calcitonin Gene Related Peptide) Antibody J Comp Neurol. 2008 Feb 1;506(4):627-39. Expression of P2X3 receptor in the trigeminal sensory nuclei of the rat. Kim YS1, Paik SK, Cho YS, Shin HS, Bae JY, Moritani M, Yoshida A, Ahn DK, Valtschanoff J, Hwang SJ, Moon C, Bae YC. Rat IF 18067147
24112 CGRP (Calcitonin Gene Related Peptide) Antibody J Comp Neurol. 2004 Oct 4;478(1):62-71. Expression of vanilloid receptor TRPV1 in the rat trigeminal sensory nuclei. Bae YC1, Oh JM, Hwang SJ, Shigenaga Y, Valtschanoff JG. Rat IF 15334649
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Nomura, Hiroshi, et al. "Extramedullary chitosan channels promote survival of transplanted neural stem and progenitor cells and create a tissue bridge after complete spinal cord transection." Tissue Engineering Part A 14.5 (2008): 649-665. Rat IHC 55 18419246
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Wotus, Cheryl, et al. "Forced desynchrony reveals independent contributions of suprachiasmatic oscillators to the daily plasma corticosterone rhythm in male rats." PloS one 8.7 (2013): e68793. Rat 4 23894346
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Yoon, Y. S., et al. "Galanin?Immunoreactive Cells and Their Relation to Calcitonin Gene?Related Peptide?, Substance P?and Somatostatin?Immunoreactive Cells in Rat Lumbar Dorsal Root Ganglia." Anatomia, histologia, embryologia 32.2 (2003): 110-115. Rat 15 12797533
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Pain. 2012 Jan;153(1):184-96. doi: 10.1016/j.pain.2011.10.014. Epub 2011 Nov 8. Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization.Tappe-Theodor A1, Constantin CE, Tegeder I, Lechner SG, Langeslag M, Lepcynzsky P, Wirotanseng RI, Kurejova M, Agarwal N, Nagy G, Todd A, Wettschureck N, Offermanns S, Kress M, Lewin GR, Kuner R. 6 22071319
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Ibanez, Marta, et al. "Human laryngeal ganglia contain both sympathetic and parasympathetic cell types." Clinical Anatomy 23.6 (2010): 673-682. Human IHC 4 20821402
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Hodgetts, Stuart I., Paul J. Simmons, and Giles W. Plant. "Human mesenchymal precursor cells (Stro-1+) from spinal cord injury patients improve functional recovery and tissue sparing in an acute spinal cord injury rat model." Cell transplantation 22.3 (2013): 393-412. Rat 3 23007022
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Ulrich-Lai, Yvonne M., and William C. Engeland. "Hyperinnervation during adrenal regeneration influences the rate of functional recovery." Neuroendocrinology 71.2 (2000): 107-123. 41 10686525
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Schueler, Paula A., et al. "Identification and Initial Characterization of Adipokinetic Hormone?Like Immunoreactive Peptides of Rat Origin." Journal of neurochemistry 47.1 (1986): 133-138. Rat 6 3711894
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Hamaue, Yohei, et al. "Immobilization-induced hypersensitivity associated with spinal cord sensitization during cast immobilization and after cast removal in rats." The Journal of Physiological Sciences 63.6 (2013): 401-408. Rat 1 23818166
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Danzer, Marion, et al. "Immunocytochemical characterization of rat brainstem neurons with vagal afferent input from the stomach challenged by acid or ammonia." European Journal of Neuroscience 19.1 (2004): 85-92. 13 not found
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Acta Histochem. 2000 Nov;102(4): 391-402.Immunocytochemical study on the liver innervation in patients with cirrhosis.Stoyanova II1, Gulubova MV. Human IHC 11145532
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Welton, Joan, et al. "Immunocytochemical survey of putative neurotransmitters in taste buds from Necturus maculosus." Journal of Comparative Neurology 324.4 (1992): 509-521. Mudpuppy (Necturus Maculosus) 27 1385495
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Abdel-Rahman, T. A., et al. "Immunohistochemical, morphological and functional changes in the peripheral sudomotor neuro-effector system in elderly people." Journal of the autonomic nervous system 37.3 (1992): 187-197. Human IHC 43 1587996
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Westermark, Tobias, et al. "Increase in bombesin-like peptides in the spinal cord after dexamethasone treatment of adrenalectomized rats." Neuroscience letters 275.3 (1999): 179-182. Rat 4 10580704
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Hayashi, Koichi, et al. "Increase of sensitivity to mechanical stimulus after transplantation of murine induced pluripotent stem cell-derived astrocytes in a rat spinal cord injury model: Laboratory investigation." Journal of Neurosurgery: Spine 15.6 (2011): 582-593. Rat IHC Stem Cell 7 21854127
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Orita, Sumihisa, et al. "Inhibiting nerve growth factor or its receptors downregulates calcitonin gene?related peptide expression in rat lumbar dorsal root ganglia innervating injured intervertebral discs." Journal of Orthopaedic Research 28.12 (2010): 1614-1620. Rat 20 20973063
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Zhang, Fang-Xiong, et al. "Inhibition of inflammatory pain by activating B-type natriuretic peptide signal pathway in nociceptive sensory neurons." The Journal of Neuroscience 30.32 (2010): 10927-10938. Rat IF 28 20702721
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Whelan, N. L., et al. "Intramyocardial arterial cushions of coronary vessels in animals and humans: morphology, occurrence and relation to heart disease." Journal of vascular research 33.3 (1996): 209-224. Human 7 8924519
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Orita, Sumihisa, et al. "I-B kinase inhibitor downregulates pain-related neuropeptide production in the sensory neurons innervating injured lumbar intervertebral discs in the dorsal root ganglia of rats." The Spine Journal 13.3 (2013): 284-288. 3 23462514
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Kim, Sung Min, et al. "Local application of capsaicin alleviates mechanical hyperalgesia after spinal nerve transection." Neuroscience letters 433.3 (2008): 199-204. IF 9 18242851
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Amaya, Fumimasa, et al. "Local inflammation increases vanilloid receptor 1 expression within distinct subgroups of DRG neurons." Brain research 963.1 (2003): 190-196. IF 174 12560124
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Harach, H. R., and U. Bergholm. "Medullary carcinoma of the thyroid with carcinoid-like features." Journal of clinical pathology 46.2 (1993): 113-117. Human IHC 11 8459030
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Huang, Chiung Hui, et al. "Mite allergen induces allergic dermatitis with concomitant neurogenic inflammation in mouse." Journal of investigative dermatology 121.2 (2003): 289-293. Mouse 49 12880420
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Niu, Jingwen, et al. "Modality-Based Organization of Ascending Somatosensory Axons in the Direct Dorsal Column Pathway." The Journal of Neuroscience 33.45 (2013): 17691-17709. Mouse IHC 1 24198362
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Ochiai, Nobuyasu, et al. "Nerve regeneration after radiofrequency application." The American journal of sports medicine 35.11 (2007): 1940-1944. Rat 18 17638710
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Ingram, Susan M., et al. "Neuronal localization of cholecystokinin mRNA in the rat brain by using in situ hybridization histochemistry." Journal of Comparative Neurology 287.2 (1989): 260-272. Rat 78 2794128
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Staines, W. A., et al. "Neurons derived from P19 embryonal carcinoma cells have varied morphologies and neurotransmitters." Neuroscience 58.4 (1994): 735-751. 102 7910670
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Vigers, Alison J., et al. "Neurotrophin-3 is expressed in a discrete subset of olfactory receptor neurons in the mouse." Journal of Comparative Neurology 463.2 (2003): 221-235. Mouse ICC 15 12815759
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Papka, Raymond E., et al. "Nitric oxide nerves in the uterus are parasympathetic, sensory, and contain neuropeptides." Cell and tissue research 279.2 (1995): 339-349. 58 7534654
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Schicho, Rudolf, et al. "Nociceptive transmitter release in the dorsal spinal cord by capsaicin-sensitive fibers after noxious gastric stimulation." Brain research 1039.1 (2005): 108-115. 32 15781052
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Tsai, Mang Hung, et al. "Novel distribution of calcitonin gene-related peptide in rodent subcommissural organs." Neuroreport 14.14 (2003): 1851-1856. IHC 2 14534434
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Engeland, W. C., C. Wotus, and J. C. Rose. "Ontogeny of innervation of rat and ovine fetal adrenals." Endocrine research 24.3-4 (1998): 889-898. Rat, Ovine (Sheep) IF 13 9888594
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Kusakabe, Tatsumi. "Ontogeny of substance P-, CGRP-, and VIP-containing nerve fibers in the amphibian carotid labyrinth of the bullfrog, Rana catesbeiana." Cell and tissue research 269.1 (1992): 79-85. Bullfrog IHC 19 1384974
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Takahashi, Norimasa, et al. "Pain relief through an antinociceptive effect after radiofrequency application." The American journal of sports medicine 35.5 (2007): 805-810. Rat 30 17267771
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Kobayashi, Shigeru, Hidezo Yoshizawa, and Shuuichi Yamada. "Pathology of lumbar nerve root compression Part 2: morphological and immunohistochemical changes of dorsal root ganglion." Journal of Orthopaedic Research 22.1 (2004): 180-188. Dog 98 14656678
24112 CGRP (Calcitonin Gene Related Peptide) Antibody J Clin Invest. 2011 Apr;121(4):1608-23. doi: 10.1172/JCI44911. Epub 2011 Mar 7. Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice. Gangadharan V1, Wang R, Ulzhöfer B, Luo C, Bardoni R, Bali KK, Agarwal N, Tegeder I, Hildebrandt U, Nagy GG, Todd AJ, Ghirri A, Häussler A, Sprengel R, Seeburg PH, MacDermott AB, Lewin GR, Kuner R. Mouse IF 21383497
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Chung, M K., et al. "Peripheral G protein coupled inwardly rectifying potassium channels are involved in ??opioid receptor?mediated anti?hyperalgesia in rat masseter muscle." European Journal of Pain 18.1 (2014): 29-38. Mouse IHC 0 23740773
24112 CGRP (Calcitonin Gene Related Peptide) Antibody J Comp Neurol. 1993 Aug 1;334(1):117-24. Peripheral peptidergic fibers of the trigeminal nerve in the olfactory bulb of the rat. Finger TE1, Böttger B. Rat IHC 35 7691899
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Abbadie, C., G. W. Pasternak, and S. A. Aicher. "Presynaptic localization of the carboxy-terminus epitopes of the ? opioid receptor splice variants MOR-1C and MOR-1D in the superficial laminae of the rat spinal cord." Neuroscience 106.4 (2001): 833-842. Rat 80 11682168
24112 CGRP (Calcitonin Gene Related Peptide) Antibody PLoS Biol. 2012;10(3):e1001283. doi: 10.1371/journal.pbio.1001283. Epub 2012 Mar 13. Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.Luo C1, Gangadharan V, Bali KK, Xie RG, Agarwal N, Kurejova M, Tappe-Theodor A, Tegeder I, Feil S, Lewin G, Polgar E, Todd AJ, Schlossmann J, Hofmann F, Liu DL, Hu SJ, Feil R, Kuner T, Kuner R. Mouse IF 22427743
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Riedl, Maureen S., et al. "Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing." The Journal of Neuroscience 29.42 (2009): 13377-13388. Rat IHC 15 19846725
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Garrison, Christopher J., Patrick M. Dougherty, and Susan M. Carlton. "Quantitative analysis of substance P and calcitonin gene-related peptide immunohistochemical staining in the dorsal horn of neuropathic MK-801-treated rats." Brain research 607.1 (1993): 205-214. Rat IHC 60 7683239
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Ulrich,Lai, Y. M., and W. C. Engeland. "Rat adrenal transplants are reinnervated: an invalid model of denervated adrenal cortical tissue." Journal of neuroendocrinology 12.9 (2000): 881-893. Rat 17 10971813
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Schicho, R., G. Skofitsch, and J. Donnerer. "Regenerative effect of human recombinant NGF on capsaicin-lesioned sensory neurons in the adult rat." Brain research 815.1 (1999): 60-69. Rat 38 9974123
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Gilchrist, Laura S., et al. "Re-organization of P2X 3 receptor localization on epidermal nerve fibers in a murine model of cancer pain." Brain research 1044.2 (2005): 197-205. Mouse cancer 39 15885218
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Legat, Franz J., et al. "Repeated subinflammatory ultraviolet B irradiation increases substance P and calcitonin gene-related peptide content and augments mustard oil-induced neurogenic inflammation in the skin of rats." Neuroscience letters 329.3 (2002): 309-313. Rat IHC 24 12183038
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Vulchanova, Lucy, et al. "Research Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture." (2010). Mouse IHC 22 20509925
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Tourtellotte, Warren G., and Jeffrey Milbrandt. "Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3." Nature genetics 20.1 (1998): 87-91. Mouse Transcription Factor 138 9731539
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Tjen-A-Looi, S., et al. "Sensory CGRP depletion by capsaicin exacerbates hypoxia-induced pulmonary hypertension in rats." Regulatory peptides 74.1 (1998): 1-10. Rat Hypoxia 18 9657352
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Ochiai, Nobuyasu, et al. "Sensory innervation of rat contracture shoulder model." Journal of Shoulder and Elbow Surgery 22.2 (2013): 158-164. IHC 1 22608933
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Vittoria, A., et al. "Serotonin-, somatostatin-and chromogranin A-containing cells of the urethro-prostatic complex in the sheep. An immunocytochemical and immunofluorescent study." Journal of anatomy 171 (1990): 169. Ram / Sheep IF 26 1981998
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Tran, Phu V., Michael K. Georgieff, and William C. Engeland. "Sodium depletion increases sympathetic neurite outgrowth and expression of a novel TMEM35 gene-derived protein (TUF1) in the rat adrenal zona glomerulosa." Endocrinology 151.10 (2010): 4852-4860. Rat 3 20685870
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Byrd, Frances, Robert Devlin, and Preston Dorsett. "Specificity in the detection of anti-rubella IgM antibodies." 0 not found
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Bedi, Supinder S., et al. "Spinal cord injury triggers an intrinsic growth-promoting state in nociceptors." Journal of neurotrauma 29.5 (2012): 925-935. Rat IF 5 21939395
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Beuschlein, Felix, et al. "Steroidogenic factor-1 is essential for compensatory adrenal growth following unilateral adrenalectomy." Endocrinology 143.8 (2002): 3122-3135. IHC 69 12130578
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Tsai, Mang Hung, et al. "Subcellular distributions of calcitonin gene-related peptide (CGRP)-like immunoreactivity in the subcommissural organ of the golden hamster (Mesocricetus auratus)." Neuroscience research 47.1 (2003): 85-95. Hamster IHC 5 12941450
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Pataky, D. M., S. B. Curtis, and A. M. J. Buchan. "The co-localization of neuropeptides in the submucosa of the small intestine of normal Wistar and non-diabetic BB rats." Neuroscience 36.1 (1990): 247-254. Rat 26 1699158
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Hwang, Se Jin, Jung Min Oh, and Juli G. Valtschanoff. "The majority of bladder sensory afferents to the rat lumbosacral spinal cord are both IB4-and CGRP-positive." Brain research 1062.1 (2005): 86-91. Rat IF 32 16263099
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Helgren, Maureen E., and Michael E. Goldberger. "The recovery of postural reflexes and locomotion following low thoracic hemisection in adult cats involves compensation by undamaged primary afferent pathways." Experimental neurology 123.1 (1993): 17-34. 106 8405276
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Legat, Franz J., et al. "The role of calcitonin gene?related peptide in cutaneous immunosuppression induced by repeated subinflammatory ultraviolet irradiation exposure." Experimental dermatology 13.4 (2004): 242-250. Mouse IHC 24 15086340
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Nolano, Maria, et al. "Topical capsaicin in humans: parallel loss of epidermal nerve fibers and pain sensation." Pain 81.1 (1999): 135-145. Human 331 10353501
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Kondo, Takashi, et al. "Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats." Gut 58.10 (2009): 1342-1352. Rat 32 19515638
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Furuya, Takeo, et al. "Treatment with basic fibroblast growth factor-incorporated gelatin hydrogel does not exacerbate mechanical allodynia after spinal cord contusion injury in rats." The journal of spinal cord medicine 36.2 (2013): 134-139. Rat IF 1 23809528
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Wacnik, Paul W., et al. "Tumor-induced mechanical hyperalgesia involves CGRP receptors and altered innervation and vascularization of DsRed2 fluorescent hindpaw tumors." Pain 115.1 (2005): 95-106. IHC 40 15836973
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Saban MR1, Davis CA, Avelino A, Cruz F, Maier J, Bjorling DE, Sferra TJ, Hurst RE, Saban R, BMC Physiol. 2011 Nov 7;11:16. doi: 10.1186/ 1472-6793-11-16. "VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG" Mouse IF 22059553
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Paik, Sang Kyoo, et al. "Vesicular glutamate transporters in axons that innervate the human dental Pulp." Journal of endodontics 38.4 (2012): 470-474. Human 1 22414831
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Schuster, D. J., et al. "Visualization of spinal afferent innervation in the mouse colon by AAV8?mediated GFP expression." Neurogastroenterology & Motility 25.2 (2013): e89-e100. Mouse IHC 2 23252426
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Cruise, Bethany A., Pin Xu, and Alison K. Hall. "Wounds increase activin in skin and a vasoactive neuropeptide in sensory ganglia." Developmental biology 271.1 (2004): 1-10. Rat IHC 41 15196945
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Takanami, Keiko, et al. "Distribution of gastrin‐releasing peptide in the rat trigeminal and spinal somatosensory systems." Journal of Comparative Neurology 522.8 (2014): 1858-1873. Rat 9 not defined
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Hamaue, Yohei, et al. "Effects of Vibration Therapy on Immobilization-Induced Hypersensitivity in Rats." Physical therapy (2015). Rat Pain 0 not defined
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Sainoh, Takeshi, et al. "Efficacy of Anti–Nerve Growth Factor Therapy for Discogenic Neck Pain in Rats." Spine 39.13 (2014): E757-E762. Rat IF Pain 2 24732837
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Sainoh, Takeshi, et al. "Interleukin‐6 and interleukin‐6 receptor expression, localization, and involvement in pain‐sensing neuron activation in a mouse intervertebral disc injury model." Journal of Orthopaedic Research (2015). Mouse Pain 0 not defined
24112 CGRP (Calcitonin Gene Related Peptide) Antibody Terada, Tadashi. "Ontogenic development of nerve fibers in human fetal livers: an immunohistochemical study using neural cell adhesion molecule (NCAM) and neuron-specific enolase (NSE)." Histochemistry and cell biology 143.4 (2014): 421-429. Human 1 25326085

Q & A Wall

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Regarding the rabbit against rat CGRP antibody (Product No: 24112) I would like to know if it stains frozen human tissues, (like punch tissue) by the immunofluorescence technique and if so, the working dilution.
Question By Fatima

We tested with immunohistochemistry on rat tissue for the CGRP antibody, but we have quite a few references using human tissue.

One highly cited publication is Abdel-Rahman, T. A., et al. "Immunohistochemical, morphological and functional changes in the peripheral sudomotor neuro-effector system in elderly people." Journal of the autonomic nervous system 37.3 (1992): 187-197.

Answer By Colleen H on 2015-01-07 13:09:14

MSDS

This product contains the preservative sodium azide. The concentration percent of the sodium azide is ≤ .09%. Although this hazardous substance is a concentration below that required for the preparation of a Material Safety Data Sheet, we created a standard MSDS for your records.

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