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5-HT (Serotonin) 7 Receptor Antibody - 24430

$375.00

Product Overview:
The histochemical antibody for 5-HT7 receptor is generated in a rabbit against synthetic peptide sequence corresponding to amino acids 8-23 of the rat 5-HT7 receptor. The antibody is provided as 100 µL of affinity purified serum containing 1% BSA.
Controls:
The ImmunoStar 5-HT7 receptor antiserum was quality control tested using standard immunohistochemical methods. The antiserum demonstrates strongly positive labeling of rat cortex and hippocampus using indirect immunofluorescent and biotin/avidin-HRP techniques. Recommended primary dilutions are 1/100 - 1/300 in PBS - biotin/avidin-HRP Technique. Note: use of Triton X-100 or other detergents is not recommended.

The antibody was characterized by immunohistochemistry. Immunohistochemical staining of rat brain correlates well with Northern blot analysis, in situ hybridization and receptor autoradiography studies. Immunolabeling is completely abolished by preadsorption with synthetic rat 5-HT7 receptor (8-23). BlastP database sequence homology searches indicate that the amino acid sequence is unique to rat 5-HT7A, 5-HT7B and 5-HT7C. There is also significant sequence overlap with the mouse and human forms.
Host: RabbitQuantity / Volume: 100 µL
State: Liquid

Download Product Spec Sheet:

5-HT (Serotonin) 7 Receptor Antibody Spec Sheet

Journal References:

  1. Characterization of serotonergic receptors in rabbit, porcine and human conjunctivae., Helen Turner, Lawrence J. Alvarez, Oscar A. Candia, and Audrey M. Bernstein, Current Eye Research, 27(4), 205-215, 2003.
  2. IMMUNOCYTOCHEMICAL DETECTION OF THE SEROTONIN TRANSPORTER IN RAT BRAIN, C. SUR,* H. BETZ and P. SCHLOSS, Neuroscience, 73, 217-231, 1996.
  3. Localization of 5-HT7 receptors in rat brain by immunocytochemistry, in situ hybridization, and agonist stimulated cFos expression, J.F. Neumaier, T.J. Sexton, J. Yracheta, A.M. Diaz, and M. Brownfield, Journal of Chemical Neuroanatomy, 21, 63-73, 2001.
  4. Pre- and Postsynaptic Localization of the 5-HT7 Receptor in Rat Dorsal Spinal Cord: Immunocytochemical Evidence, Stephane Doly, Jacqueline Fischer, Marie-Jeanne Brisorgueil, Daniel Verge, and Marie Conrath, The Journal of Comparative Neurology, 490, 256–269 , 2005.

Add to Cart:

  • Product Number: 24430


This product was added to our catalog on Tuesday 08 January, 2008.
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