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5-HT (Serotonin) Rabbit Antibody - 20080

$260.00

Product Overview:
The histochemical antibody for serotonin is generated in a rabbit against serotonin coupled to bovine serum albumin with paraformaldehyde. The antiserum is provided as l00 µL of lyophilized whole serum, and 0.09% sodium azide.
Controls:
The ImmunoStar serotonin antiserum was quality control tested using standard immunohistochemical methods. The antiserum demonstrates strongly positive labeling of rat hypothalamus, raphe nuclei and spinal cord using indirect immunofluorescent and biotin/avidin-HRP techniques. Recommended primary dilutions are 1/1,000-1/2,000 in PBS/0.3% Triton X-100 - Cy3 Technique and 1/20,000-1/40,000 in PBS/0.3% Triton X-100 - biotin/avidin-HRP Technique. Staining is completely eliminated by pretreatment of the diluted antibody with 25 ug of serotonin/BSA.

Cross reactivity of Serotonin antisera was examined. With 5µg, 10µg and 25µg amounts the following substances did not react with Serotonin antisera diluted 1/20,000 using the Bn-SA/HRP labeling method: 5-hydroxytryptophan, 5-hydroxyindole -3- acetic acid, and dopamine.
Host: RabbitQuantity / Volume: 100 µL
State: lyophilized

Download Product Spec Sheet:  5-HT (Serotonin) Rabbit Antibody Spec Sheet

Journal References:

  1. Evidence that serotonin reuptake modulators increase the density of serotonin innervation in the forebrain, Zhou, Huang, Kecojevic, Welsh, Koliatsos, Journal of Neurochemistry, 396(2), 396-?, 2006.
  2. A paracrine signaling role for serotonin in rat taste buds: expression and localization of serotonin receptor subtypes, Kaya N, Shen T, Lu S-g, Zhao  F-l, and Herness S , AJP-Regulatory, Integrative, and Comparative Physiology, 286, R649-R658 , 2004. 
  3. A soluble Nogo receptor differentially affects plasticity of spinally projecting axons , MacDermid VE, McPhail LT, Tsang B, Rosenthal A , Davies A, Ramer MS, European Journal of Neuroscience Adult Motor Neuron Apoptosis Is Mediated by Nitric Oxide and Fas Death Receptor Linked by DNA Damage and p53 Activation, Lee J. Martin,1,2 Kevin Chen,1 and Zhiping Liu1, The Journal of Neuroscience, 25(27), 6449–6459, 2005 Alpha 4 nicotinic acetylcholine receptor subunit links cholinergic to brainstem monoaminergic neurotransmission., Cucchiaro G, Commons KG, Synapse, 49(3), 195-205, 2003.
  4. Basic Fibroblast Growth Factor Promotes Neuronal Survival but Not Behavioral Recovery in the Transected and Schwann Cell Implanted Rat Thoracic Spinal Cord, Meijs MFL, Timmers L, Pearse DP, Tresco PA, et al, Journal of Neurotrauma, 21 (#10), 1415-1430, 2004.
  5. BDNF Promotes the Regenerative Sprouting, But Not Survival, of Injured Serotonergic Axons in the Adult Rat Brain, Mamounas LA , Altar CA , Blue ME , The Journal of Neuroscience, 20(2), 771-782, 2000.
  6. Blockade of Nogo-66, Myelin-Associated Glycoprotein, and Oligodendrocyte Myelin Glycoprotein by Soluble Nogo-66 Receptor Promotes Axonal Sprouting and Recovery after spinal injury, S. Li, Liu, Budel, M. Li, B. Ji, Walus, W. Li, Jirik, Rabacchi, Choi, Worley, Sah, Pepinsky, Lee, Relton, Strittmatter, The Journal of Neuroscience, 24(46), 10511-10520, 2004.
  7. Calbindin and calretinin immunoreactivities identify different types of neurons in the adult lamprey spinal cord., Megias M, Alvarez-Otero R, Pombal MA, J Comp Neurol , 455(1), 72-85, 2002. 
  8. Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination., Blesch A, Tuszynski MH, J Comp Neurol , 467(3), 403-417, 2003, 
  9. Colocalization of serotonin and vesicular glutamate transporter 3-like immunoreactivity in the midbrain raphe of Syrian hamsters (Mesocricetus auratus), Mintz, Scott, Neuroscience letters, 394, 97-100, 2006.
  10. Coordination of the Bladder Detrusor and the External Urethral Sphincter in a Rat Model of Spinal Cord Injury:  Effect of Injury Severity, V. Pikov, J.R. Wrathall, The Journal of Neuroscience, 21(2), 559-569, 2001. 
  11. Cuneiform Neurons Activated during Cholinergically Induced Active Sleep in the Cat, I. Pose, S. Sampogna, M.H. Chase, The Journal of Neuroscience, 20(9), 3319-3327, 2000.
  12. Deafferentation and neurotrophin-mediated intraspinal sprouting: a central role for the p75 neurotrophin receptor, Angela L. M. Scott,1,2 Jaimie F. Borisoff1,2,3 and Matt S. Ramer, European Journal of Neuroscience, 21, 81–92, 2005.
  13. Differential expression of nitric oxide in serotonergic projection neurons: Neurochemical identification of dorsal raphe inputs to rodent trigeminal somatosensory targets. , Simpson KL, Waterhouse BD, Lin RCS, J Comp Neurol , 466(4), 495-512, 2003.
  14. Dynamic Patterned Expression of Orphan Nuclear Receptor Genes RORα and RORβ in Developing Mouse Forebrain, Nakagawa Y, and O'Leary D, Dev Neurosci, 25, 234-244, 2003.
  15. EMX2 Regulates Size and Positioning of the Primary Sensory and Motor Areas in Neocortex by Direct Specification of Cortical Progenitors, Hamasaki, Leingartner, Ringstedt, O'Leary, Neuron, 43, 359-372, 2004.
  16. Evolution of learning in three aplysiid species: differences in heterosynaptic plasticity contrast with conservation in serotonergic pathways, Marinesco S, Duran KL and Wright WG, The Journal of Physiology, 550.1, 241-253, 2003.
  17. Examining the Role of Paneth Cells in the Small Intestine by Lineage Ablation in Transgenic Mice, Garabedian EM, Robberts LJJ, McNevin MS, The Journal of Biological Chemistry, 272(38), 23729-23740, 1997.
  18. Gene expression is required for correct axon guidance., Condron, B, Department of Biology, , 2003 Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation, Shroyer, Wallis,Venken ,Bellen, Zoghbi , GENES & DEVELOPMENT, 19, 2412-2417, 2005.
  19. Histamine Compartments of the Drosophila Brain With an Estimate of the Quantum Content at the photoreceptor synapse, J. A. Borycez, J Borycez, Kubow, Kostyleva, Meinertzhagen, Journal of Neurophysiology, 93, 1611-1619, 2004
  20. Histamine Infusion Induces a Selective Dopaminergic Neuronal Death Along with an Inflammatory Reaction in Rat Substantia Nigra, M.L. Vizuete, M. Merino, J.L. Venero, Journal of Neurochemistry, 75(2), 540-552, 2000.
  21. Identification and Characterization of tachykinin-containing neuroendocrine organ in the commissural ganglion of the crab Cancer productus, Messinger D, Kutz K, Le T, Verley D, Hsu Y, Ngo C, Cain S, Birmingham J, Li L, Christie A, The Journal of Experimental Biology, 208, 3303-3319, 2005.
  22. Immunohistochemical Characterization of Proliferating Cells in the Hypothalamus of Adult Tiger Salamanders, Porter M, and Orchinik M, Department of Nutrition and Department of Biology, 2003.
  23. In vivo interaction between serotonin and galanin receptors types 1 and 2 in the dorsal raphe: implication for limbic seizures, Andrey M. Mazarati,*, Roger A. Baldwin, Steve Shinmei and Raman Sankar*, Journal of Neurochemistry, 95, 1495–1503, 2005.
  24. Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson’s disease, Alexander J. Whitworth*†, Dorothy A. Theodore‡§, Jessica C. Greene*, Helen Benesˇ¶, Paul D. Wes‡§, and Leo J. Pallanck*, PNAS, 102 (22), 8024–8029, 2005.
  25. Lamina Propria and Olfactory Bulb Ensheathing Cells Exhibit Differential Integration and Migration and Promote Differential Axon Sprouting in the Lesioned Spinal Cord, Miranda W. Richter,1 Patrick A. Fletcher,1 Jie Liu,2 Wolfram Tetzlaff,2 and A. Jane Roskams1, The Journal of Neuroscience, 25(46), 10700 –10711, 2005.
  26. Lessen encodes a zebrafish trap100 required for enteric nervous system development, Pietsch, Delalande, Jakaitis, Stensby, Dohle,  Talbot, Raible and Shepherd, Development, 133, 395-406, 2006.
  27. Lmx1b, Pet-1, and Nkx2.2 Coordinately Specify Serotonergic Neurotransmitter Phenotype , Cheng L, Chen C-L, Luo P,Tan  M, Qiu M, Johnson R, and Ma Q, , The Journal of NeuroScience, 23(31), 9961-9967, 2003.
  28. Mast Cells Migrate from Blood to Brain, A.J. Silverman, A.K. Sutherland, M. Wilhelm, The Journal of Neuroscience, 20(1), 401-408, 2000.
  29. Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus, Amat J, Baratta MV, Paul E , Bland  ST, Watkins LR , and Maier SF, Nature Neuroscience, 8, 365-371, 2005.
  30. Median And Dorsal Raphe Neurons Are Not Electrophysiologically Identical, Beck SG, Pan Y-Z, Akanwa AC, Kirby LG, Journal of Neurophysiology, 91, 994-1005, 2003.
  31. Midline serotonergic neurones contribute to widespread synchronized activity in embryonic mouse hindbrain, Hunt, McCabe, Bosma, The Journal of Physiology, 566(3), 807-819, 2005.
  32. Neuroanatomy of sea spiders implies an appendicular origin of the protocerebral segment, Amy Maxmen1, William E. Browne3, Mark Q. Martindale3 & Gonzalo Giribet2, Nature , 437, 1144-1148, 2005.
  33. Neurochemical Brain Groups Activated After Isotonic Blood Volume Expansion in Rats, Godino, Giusti-Paiva, Antunes-Rodrigues, Vivas, Neuroscience, 133, 493-505, 2005.
  34. Neurochemical Brain Groups Activated After Isotonic Blood Volume Expansion in Rats, Godino, Giusti-Paiva, Antunes-Rodrigues, Vivas, Neuroscience, 133, 493-505, 2005.
  35. Neuromodulatory complement of the pericardial organs in the embryonic lobster, Homarus americanus., Pulver SR, Marder E, J Comp Neurol , 451(1), 79-90, 2002.
  36. Paradoxical Actions of the Serotonin Precursor 5-hydroxytryptophan on the Activity of Identified Serotonergic Neurons in a Simple Motor Circuit, Fickbohm DJ, Katz PS, The Journal of Neuroscience, 20(4), 1622-1634, 2000.
  37. Pharmacological Manipulation of Serotonin Levels in the Nervous System of the Opisthobranch Mollusc Tritonia diomedea, Fickbohm, Spitzer and Katz , Biol. Bull, 209, 67-74, 2005
  38. Prefrontal cortex serotonin, stress, and morphine-induced nucleus accumbens dopamine., Bland, Schmid, Watkins, Maier, NeuroReport, 15(17), 2637-2641, 2004.
  39. Rho-Kinase Inhibition Enhances Axonal Plasticity and Attenuates Cold Hyperalgesia after Dorsal Rhizotomy, Leanne M. Ramer,1,2* Jaimie F. Borisoff,1,2,3* and Matt S. Ramer1,2, The Journal of Neuroscience, 24(48), 10796 –10805, 2004.
  40. Robo2 and Robo3 Interact with Eagle to Regulate Serotonergic Neuron Differentiation, Couch JA, Chen J, Rieff HI, Uri EM, Condron BG, University of Virginia, 131, 997-1006, 2003
  41. Selective Activation of Corticotropin-Releasing Factor-2 Receptors on Neurochemically Identified Neurons in the RatDorsal Raphe Nucleus Reveals Dual Actions, Luise Pernar,1 Andre L. Curtis,1 Wylie W. Vale,2 Jean E. Rivier,2 and Rita J. Valentino1, Behavioral/Systems/Cognitive, 24(6),  1305–1311, 2004.
  42. Serotonin Modulates the Suppressive Effects of Corticosterone on Proliferating Progenitor Cells in the Dentate Gyrus of the Hippocampus in the Adult Rat, Huang,  Herbert, Neuropsychopharm-acology, 30, 231-241, 2005. 
  43.  Serotonin Regulates Rhythmic Whisking, Hattox A, Li Y, Keller A, Neuron, 39, 343-352, 2003.
  44. Somatodendritic autoreceptor regulation of serotonegic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinase, Liu, Lambe, Aghajanian, European Journal of Neuroscience, 21, 945-958, 2005.
  45. Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region, Blaess, Corrales, Joyner, Development, 133, 1799-1809, 2005.
  46. Stromal cell-derived inducing activity does not promote dopaminergic differentiation, but enhances differentiation and proliferation of neural stem cell-derived astrocytes, Roybon, Brudin, Li, Experimental Neurology, (1-8), 2005.
  47. The development of the larval nervous system, musculature and ciliary bands of Pomatoceros lamarckii (Annelida): heterochrony inpolychaetes, Carmel McDougall, Wei-Chung Chen, Sebastian M Shimeld andDavid EK Ferrier*, BioMed Central, 3:16, 1 to 14, 2006.
  48. The distribution and morphological characteristics of serotonergic cells in the brain of monotremes., Manger PR, Fahringer HM, Pettigrew JD, Siegel JM, Brain Behav Evol, 60, 315-332, 2002.
  49. The impact of graft size on the development of dyskinesia following intrastriatal grafting  of embryonic dopamine neurons in  the rat, Lane, Winkler, Brundin, Cenci, Neurobiology of Disease, (1-12), 2005.
  50. Transplantation of Neuronal and Glial Restricted Precursors into Contused Spinal Cord Improves Bladder and Motor Functions, Decreases Thermal Hypersensitivity, and Modifies Intraspinal Circuitry, Mitsui, Shumsky, Lepore, Murray, Fischer, The Journal of Neuroscience, 25(42), 9624-9636, 2005.


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  • Product Number: 20080


This product was added to our catalog on Tuesday 22 January, 2008.
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