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Somatostatin Antibody

Somatostatin Antibody
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Price: $250.00
Product ID : 20067
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Description

The antibody has a proven strong indirect immunofluorescent staining at a 1/400-1/800 dilution and strong Biotin-Streptavidin/HRP staining at a 1/1000-1/2000 dilution in rat hypothalamus (median eminence). The specificity of the antiserum was examined by soluble pre-adsorption with the peptides in question at a final concentration of 106M.

Somatostatin immunolabeling was completely abolished by pre-adsorption with somatostatin, somatostatin 25, and somatostatin 28. Pre-adsorption with the following peptides resulted in no reduction of immunostaining: substance P, amylin, glucagon, insulin, neuropeptide Y, and VIP.

Photo Description: IHC image of the median eminence staining for somatostatin (above). The tissue was fixed with 4% formaldehyde in phosphate buffer, before being removed and prepared for vibratome sectioning. Floating sections were incubated at RT in 10% goat serum in PBS, before standard IHC procedure. Primary antibody was incubated at 1:5000 for 48 hours, goat anti-rabbit secondary was subsequently added for 1 hour after washing with PBS. Light microscopy staining was achieved with standard biotin-streptavidin/HRP procedure and DAB chromogen. Florescent secondary (below).

Somatostatin median eminence #20067

Host: Rabbit

Quantity / Volume:  100 µL

State: Lyophilized Whole Serum

Reacts With: Amphibian, Chicken, Fish, Frog, Human, Monkey, Mouse, Rat, Stingray

Availability: In Stock

Preabsorption Control: Available at Sigma Aldrich, Catalog # S9129

Alternate Names:  Growth hormone release-inhibiting factor; Somatostatin 14; Somatostatin 28; prepro-somatostatin; SMST; somatostatin   

Gene Symbol / ID, Accession #:  SST, 6750

 

Download Product Spec. SheetSomatostatin Antibody

 

Journal References:


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Silvia Pagliardini, Jun Ren, Paul A. Gray, Cassandra VanDunk, Michael Gross, Martyn Goulding, and John J. Greer; Central Respiratory Rhythmogenesis Is Abnormal in Lbx1-Deficient Mice; Journal of Neuroscience,,28(43):11030 –11041 (2008), Tested in Mouse, PubMed ID: 18945911

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Lucini, Carla, et al. "Trk-neurotrophin receptor-like immunoreactivity in the gut of teleost species." Cell and tissue research 296.2 (1999): 323-330. PubMed ID: 10408916

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Omura, Nobuo, et al. "Effect of pirenzepine on gastric endocrine cell kinetics during lansoprazole administration." Journal of gastroenterology 33.5 (1998): 634-639. PubMed ID: 9773926

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Lucini, C., et al. "Ontogeny, postnatal development and ageing of endocrine pancreas in Bubalus bubalis." Journal of anatomy 192.3 (1998): 417-424. Tested in Bubalus Bubalis (Buffalo), PubMed ID: 9688507

McMahon, C. D., et al. "Stimulation of Dopamine D 1 Receptors Increases Activity of Periventricular Somatostatin Neurons and Suppresses Concentrations of Growth Hormone." Domestic animal endocrinology 15.4 (1998): 257-265. PubMed ID: 9673457

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Myrsén-Axcrona, Ulrika, et al. "Dexamethasone Induces Neuropeptide Y (NPY) Expression and Impairs Insulin Release in the Insulin-producing Cell Line RINm5F RELEASE OF NPY AND INSULIN THROUGH DIFFERENT PATHWAYS." Journal of Biological Chemistry 272.16 (1997): 10790-10796. Tested in Rat, PubMed ID: 9099732

Naya, Francisco J., et al. "Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice." Genes & Development 11.18 (1997): 2323-2334. Tested in Mouse, PubMed ID: 9308961

Gremlich, Sandrine, et al. "Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels." Journal of Biological Chemistry 272.48 (1997): 30261-30269. Tested in Rat, PubMed ID: 9374511

Repetti, C. F., W. A. Baughman, and V. Shanabrook. "Flow cytometric characterization of a distinct presentation of “biphenotypic” acute leukemias." Clinical Immunology Newsletter 17.6 (1997): 89-90.

Thompson, K., et al. "Hippocampal stimulation produces neuronal death in the immature brain." Neuroscience 82.2 (1997): 337-348. PubMed ID: 9466446

Kaleczyc, J., et al. "Immunohistochemical characteristics of nerve fibres supplying the porcine vas deferens. A colocalisation study." Histochemistry and cell biology 107.3 (1997): 229-241. PubMed ID: 9105894

Asan, Esther. "Interrelationships between tyrosine hydroxylase-immunoreactive dopaminergic afferents and somatostatinergic neurons in the rat central amygdaloid nucleus." Histochemistry and cell biology 107.1 (1997): 65-79. Tested in Rat, PubMed ID: 9049643

Dheen, S. T., K. Rajkumar, and L. J. Murphy. "Islet cell proliferation and apoptosis in insulin-like growth factor binding protein-1 in transgenic mice." Journal of endocrinology 155.3 (1997): 551-558. Tested in Mouse, PubMed ID: 9488000

Hishima, Tsunekazu, et al. "Neuroendocrine Differentiation in Thymic Epithelial Tumors." Epithelial Tumors of the Thymus. Springer US, 1997. 67-73. PubMed ID: 9563781

Cummings, Sharon L. "Neuropeptide Y, somatostatin, and cholecystokinin of the anterior piriform cortex." Cell and tissue research 289.1 (1997): 39-51. PubMed ID: 9182599

Matsuda, H. I. D. E. K. I., et al. "Neuropeptide-containing nerve fibres in the human parotid gland: a semiquantitative analysis using an antibody against protein gene product 9.5." The Histochemical Journal 29.7 (1997): 539-544. Tested in Human, PubMed ID: 9279556

Sjölund, K., et al. "Neuropeptides in idiopathic chronic constipation (slow transit constipation)." Neurogastroenterology & Motility 9.3 (1997): 143-150. PubMed ID: 9347469

Bottjer, S. W., H. Roselinsky, and N. B. Tran. "Sex Differences in Neuropeptide B Staining of Song-Control Nuclei in Zebra Finch Brains (Part 1 of 2)." Brain, behavior and evolution 50.5 (1997): 284-293. Tested in Bird.

Ordónez, Nelson G., Karen R. Cleary, and Bruce Mackay. "Small cell undifferentiated carcinoma of the pancreas." Ultrastructural pathology 21.5 (1997): 467-474. PubMed ID: 9273978

Markakis, Eleni A., and Larry W. Swanson. "Spatiotemporal patterns of secretomotor neuron generation in the parvicellular neuroendocrine system." Brain research reviews 24.2 (1997): 255-291. Tested in Rat, PubMed ID: 9385456

Stellrecht, Christine MM, et al. "Tissue-specific and developmental regulation of the rat insulin II gene enhancer, RIPE3, in transgenic mice." Journal of Biological Chemistry 272.6 (1997): 3567-3572. Tested in Mouse, PubMed ID: 9013607

Medina, Loreta, Griselle Figueredo-Cardenas, and Anton Reiner. "Differential abundance of superoxide dismutase in interneurons versus projection neurons and in matrix versus striosome neurons in monkey striatum." Brain research 708.1 (1996): 59-70. Tested in Monkey, PubMed ID: 8720860

Mulder, H., B. Ahrén, and F. Sundler. "Islet amyloid polypeptide (amylin) and insulin are differentially expressed in chronic diabetes induced by streptozotocin in rats." Diabetologia 39.6 (1996): 649-657. Tested in Rat, PubMed ID: 8781760

Dawson, Valina L., et al. "Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice." The Journal of neuroscience 16.8 (1996): 2479-2487. Tested in Mouse, PubMed ID: 8786424

Jolkkonen, Jukka, et al. "Seizure-induced damage to the hippocampus is prevented by modulation of the GABAergic system." Neuroreport 7.12 (1996): 2031-2035. PubMed ID: 8905719

Letini, Krešimir, and Ivica Kostovi. "Transient neuronal population of the internal capsule in the developing human cerebrum." Neuroreport 7.13 (1996): 2159-2162. Tested in Human, PubMed ID: 8930980

Ahmed, Shireen, Brent A. Reynolds, and Samuel Weiss. "BDNF enhances the differentiation but not the survival of CNS stem cell-derived neuronal precursors." The Journal of neuroscience 15.8 (1995): 5765-5778. Tested in Mouse, PubMed ID: 7643217

Jen, P. Y., and J. S. Dixon. "Development of peptide-containing nerves in the human fetal prostate gland." Journal of anatomy 187.Pt 1 (1995): 169. Tested in Human, PubMed ID: 7591978

Jen, P. Y. P., J. S. Dixon, and J. A. Gosling. "Development of peptide‐containing nerves in the human fetal vas deferens and seminal vesicle." British journal of urology 75.3 (1995): 378-385. Tested in Human, PubMed ID: 7735805

Mulder, H., B. Ahrén, and F. Sundler. "Differential expression of islet amyloid polypeptide (amylin) and insulin in experimental diabetes in rodents." Molecular and cellular endocrinology 114.1 (1995): 101-109. PubMed ID: 8674834

Mulder, H., et al. "Non-parallelism of islet amyloid polypeptide (amylin) and insulin gene expression in rat islets following dexamethasone treatment." Diabetologia 38.4 (1995): 395-402. Tested in Rat, PubMed ID: 7796979

Watt, Carl B., and Valarie J. Florack. "A triple-label analysis demonstrating that enkephalin-, somatostatin-and neurotensin-like immunoreactivities are expressed by a single population of amacrine cells in the chicken retina." Brain research 634.2 (1994): 310-316. Tested in Chicken, PubMed ID: 7907525

Ma, Pokay M. "Catecholaminergic systems in the zebrafish. I. Number, morphology, and histochemical characteristics of neurons in the locus coeruleus." Journal of Comparative Neurology 344.2 (1994): 242-255. Tested in Fish, PubMed ID: 8077459

Nagao, Masahiro, et al. "Differential localization of lectin binding sites and neuropeptides in human dorsal root ganglia." Histochemistry 102.4 (1994): 279-286. Tested in Human, PubMed ID: 7531191

Burg, Matthias, D. Scott Zahm, and Mark M. Knuepfer. "Immunocytochemical co-localization of substance P and calcitonin gene-related peptide in afferent renal nerve soma of the rat." Neuroscience letters 173.1 (1994): 87-93. Tested in Rat, PubMed ID: 7524001

Sugitani, Atsushi, James C. Reynolds, and Satoru Todo. "Immunohistochemical study of enteric nervous system after small bowel transplantation in humans." Digestive diseases and sciences 39.11 (1994): 2448-2456. Tested in Human, PubMed ID: 7956615

Vanhatalo, Sampsa, and Seppo Soinila. "NADPH-diaphorase activity and its colocalization with transmitters and neuropeptides in the postganglionic neurons of the rat superior cervical ganglion." Brain research 652.1 (1994): 107-112. Tested in Rat, PubMed ID: 7953706

Ardelt, A. A., N. A. Flaris, and K. A. Roth. "Neurotrophin-4 selectively promotes survival of striatal neurons in organotypic slice culture." Brain research 647.2 (1994): 340-344. PubMed ID: 7922509

McDowell, Elizabeth M., Sergei P. Sorokin, and Richard F. Hoyt Jr. "Ontogeny of endocrine cells in the respiratory system of Syrian golden hamsters." Cell and tissue research 275.1 (1994): 143-156. Tested in Hamster, PubMed ID: 8118841

Böttcher, G., et al. "Pancreatic peptide YY in alloxan diabetic mice." Pancreas 9.4 (1994): 469-474. Tested in Mouse, PubMed ID: 7937696

Figueredo-Cardenas, G., et al. "Relative survival of striatal projection neurons and interneurons after intrastriatal injection of quinolinic acid in rats." Experimental neurology 129.1 (1994): 37-56. Tested in Rat, PubMed ID: 9270055

Penix, LaRoy P., and Claude G. Wasterlain. "Selective protection of neuropeptide containing dentate hilar interneurons by non-NMDA receptor blockade in an animal model of status epilepticus." Brain research 644.1 (1994): 19-24. PubMed ID: 8032945

Murakami, Shizuko, and Yasumasa Arai. "Transient expression of somatostatin immunnoreactivity in the olfactory-forebrain region in the chick embryo." Developmental brain research 82.1 (1994): 277-285. Tested in Chick, PubMed ID: 7842515

Altemus, Margaret, et al. "CSF somatostatin in obsessive-compulsive disorder." American Journal of Psychiatry 150 (1993): 460-460. PubMed ID: 8094599

El‐Bohy, Ashraf, and Carole C. Lamotte. "Deafferentation‐induced changes in neuropeptides of the adult rat dorsal horn following pronase injection of the sciatic nerve." Journal of Comparative Neurology 336.4 (1993): 545-554. Tested in Rat, PubMed ID: 7503999

Gordon, L., et al. "Development of the peptidergic innervation of human heart." Journal of anatomy 183.Pt 1 (1993): 131. Tested in Human, PubMed ID: 7505778

Berk, Mitchell L., Stacy E. Smith, and Lee A. Mullins. "Distribution, parabrachial region projection, and coexistence of neuropeptide and catecholamine cells of the nucleus of the solitary tract in the pigeon." Journal of Comparative Neurology 327.3 (1993): 416-441. Tested in Pigeon, PubMed ID: 7680049

Tiu, S. C., et al. "Habenulo-interpeduncular descending pathways and their relationship to enkephalin-and somatostatin-immunoreactive neurons in the interpeduncular nucleus of human fetuses." Neuroscience 53.2 (1993): 489-493. Tested in Human, PubMed ID: 8098514

Lopez, J., et al. "Immunocytochemical study of the lung of domestic fowl and pigeon: endocrine cells and nerves." Cell and tissue research 273.1 (1993): 89-95. Tested in Fowl and Pigeon.

Smith, Robin L., Harriet Baker, and Charles A. Greer. "Immunohistochemical analyses of the human olfactory bulb." Journal of Comparative Neurology 333.4 (1993): 519-530. Tested in Human, PubMed ID: 7690371

Martinez, Alfredo, et al. "Localization of amidating enzymes (PAM) in rat gastrointestinal tract." Journal of Histochemistry & Cytochemistry 41.11 (1993): 1617-1622. Tested in Rat, PubMed ID: 8409369

Berk, Mitchell L., Stacy E. Smith, and Harvey J. Karten. "Nucleus of the solitary tract and dorsal motor nucleus of the vagus nerve of the pigeon: Localization of peptide and 5‐hydroxytryptamine immunoreactive fibers." Journal of Comparative Neurology 338.4 (1993): 521-548. Tested in Pigeon, PubMed ID: 8132859

Naito, Nobuko, et al. "Ontogeny of pituitary cell-types and the hypothalamo-hypophysial relationship during early development of chum salmon, Oncorhynchus keta." Cell and tissue research 272.3 (1993): 429-437.

Fontanesi, Gigliola, Giovanna Traina, and Paola Bagnoli. "Somatostatin-like immunoreactivity in the pigeon visual system: developmental expression and effects of retina removal." Visual neuroscience 10.02 (1993): 271-285. Tested in Pigeon, PubMed ID: 8097928

Hogan, Dale, and Nancy EJ Berman. "The development of somatostatin immunoreactive neurons in cat visual cortical areas." Developmental brain research 71.2 (1993): 221-238. Tested in Cat, PubMed ID: 8098274

Davidoff, M. S., et al. "The Leydig cell of the human testis—a new member of the diffuse neuroendocrine system." Cell and tissue research 271.3 (1993): 429-439. Tested in Human, PubMed ID: 8472301

Ohno, Masuo, et al. "Working memory deficits following muscarinic blockade combined with depletion of brain somatostatin in rats." Brain research 610.2 (1993): 348-353. Tested in Rat, PubMed ID: 8100474

Burkhardt‐Holm, Patricia, and Susanne Holmgren. "A study of the alimentary canal of the brachyopterygian fish Polypterus senegalus with electron microscopy and immunohistochemistry." Acta Zoologica 73.2 (1992): 85-94.

KUSAKABE, Tatsumi, and Tadashi KAWAKAMI. "Distribution of CGRP, Substance P VIP and Somatostatin Immunoreactive Nerve Fibers in the Internal Gills of Larvae of the Bullfrog, Rana ca tesbeiana." Arch. Histol. Cytol 55.3 (1992): 243-249. Tested in Bullfrog, PubMed ID: 1384606

Balaguer, L., J. Romano, and P. Ruiz-Pesini. "Localization of serotonin, cholecystokinin and somatostatin immunoreactivity in the lower respiratory tract of embryonic, foetal and postnatal sheep." (1992). Tested in Sheep, PubMed ID: 1360850

Gábriel, Robert, Márta Wilhelm, and Charles Straznicky. "Microtubule-associated protein 2 (MAP2)-immunoreactive neurons in the retina of Bufo marinus: colocalisation with tyrosine hydroxylase and serotonin in amacrine cells." Cell and tissue research 269.1 (1992): 175-182. PubMed ID: 1358449

Ellenberger, H. H., et al. "Multiple putative neuromessenger inputs to the phrenic nucleus in rat." Journal of Chemical Neuroanatomy 5.5 (1992): 375-382. Tested in Rat, PubMed ID: 1384555

White, C. A., and L. M. Chalupa. "Ontogeny of somatostatin immunoreactivity in the cat retina." Journal of Comparative Neurology 317.2 (1992): 129-144. Tested in Cat, PubMed ID: 1349313

Hernández, MP García, and B. Agulleiro. "Ontogeny of the endocrine pancreas in sea bass (Dicentrarchus labrax)." Cell and tissue research 270.2 (1992): 339-352. Tested in Sea Bass (Fish), PubMed ID: 2185122

Du, Chuang, Jeffrey L. Conklin, and Glenn Hammer. "Enteric neural modulation of slow-wave activity in cat colon." Digestive diseases and sciences 36.6 (1991): 719-726. Tested in Cat, PubMed ID: 1674468

Roth, Kevin A., et al. "Expression of liver fatty acid-binding protein/human growth hormone fusion genes within the enterocyte and enteroendocrine cell populations of fetal transgenic mice." Journal of Biological Chemistry 266.9 (1991): 5949-5954. Tested in Mouse, PubMed ID: 1706343

Cipolloni, P. B., and D. N. Pandya. "Golgi, histochemical, and immunocytochemical analyses of the neurons of auditory-related cortices of the rhesus monkey." Experimental neurology 114.1 (1991): 104-122. Tested in Monkey, PubMed ID: 1915728

Renaud, Fernando L., et al. "Hormones and signal transduction in protozoa." Comparative Biochemistry and Physiology Part A: Physiology 100.1 (1991): 41-45.

Elbal, M. T., A. Garcia Ayala, and B. Agulleiro. "Light and electron microscopic immunocytochemical demonstration of the coexistence of somatostatin 14-and somatostatin 25-like peptides in endocrine cells of the stomach of< i> Sparus aurata(teleost)." General and comparative endocrinology 84.1 (1991): 36-43. Tested in Sparus Aurata (Fish), PubMed ID: 1685719

Arihiro, Koji, and Kouki Inai. "Malignant Islet Cell Tumor of the Pancreas with Multiple Hormone Production and Expression of CEA and CA19‐9." Pathology International 41.2 (1991): 150-157. PubMed ID: 1675032

Buchan, A. M. J. "Neurofilament M and calbindin D 28k are present in mutually exclusive subpopulations of enteric neurons in the rat submucous plexus." Brain research 538.1 (1991): 171-175. Tested in Rat, PubMed ID: 1708305

Schulze, W., et al. "Neuron‐specific enolase‐like immunoreactivity in human Leydig cells." Andrologia 23.4 (1991): 279-283. Tested in Human, PubMed ID: 1772141

Donow, Christian, et al. "Nuclear DNA content in 27 pancreatic endocrine tumours: correlation with malignancy, survival and expression of glycoprotein hormone alpha chain." Virchows Archiv A 419.6 (1991): 463-468. PubMed ID: 1750193

Homberg, U., N. T. Davis, and J. G. Hildebrand. "Peptide‐immunocytochemistry of neurosecretory cells in the brain and retrocerebral complex of the sphinx moth Manduca sexta." Journal of comparative neurology 303.1 (1991): 35-52. Tested in Manducta Sexta (Moth), PubMed ID: 1706364

Ding, Wei-Guang, et al. "Phylogenetic study of serotonin-immunoreactive structures in the pancreas of various vertebrates." Cell and tissue research 263.2 (1991): 237-243. PubMed ID: 1672509

Martin, L. J., et al. "Social deprivation of infant rhesus monkeys alters the chemoarchitecture of the brain: I. Subcortical regions." The Journal of neuroscience 11.11 (1991): 3344-3358. Tested in Monkey, PubMed ID: 1682426

Klöppel, G., et al. "Solid-cystic (papillary-cystic) tumours within and outside the pancreas in men: report of two patients." Virchows Archiv A 418.2 (1991): 179-183. Tested in Human, PubMed ID: 1705067

Coulombe, James N., and Rae Nishi. "Stimulation of somatostatin expression in developing ciliary ganglion neurons by cells of the choroid layer." The Journal of neuroscience 11.2 (1991): 553-562. Tested in Chicken, PubMed ID: 1671409

White, C. A., and L. M. Chalupa. "Subgroup of alpha ganglion cells in the adult cat retina is immunoreactive for somatostatin." Journal of comparative neurology 304.1 (1991): 1-13. Tested in Cat, PubMed ID: 1673129

Martin, L. J., et al. "The striatal mosaic in primates: patterns of neuropeptide immunoreactivity differentiate the ventral striatum from the dorsal striatum." Neuroscience 43.2 (1991): 397-417. PubMed ID: 1681464

Lamotte, Carole C., and Christine M. Shapiro. "Ultrastructural localization of substance P, met‐enkephalin, and somatostatin immunoreactivity in lamina X of the primate spinal cord." Journal of comparative neurology 306.2 (1991): 290-306. Tested in Monkey, PubMed ID: 1711056

Rosin DL, Chang DA, Guyenet PG.; Afferent and efferent connections of the rat retrotrapezoid nucleus; J Comp Neurol.,122(6):745-752 (1990), Tested in Rat, PubMed ID: 16958085

Ueyama, Teizo, and Tetsuo Sugimoto. "Afferent components of nerves innervating the lower extremity: Termination in the gracile and adjacent precerebellar nuclei of the cat." Neuroscience Research Supplements 11 (1990): S136. Tested in    Cat.

Bjartell, Anders, et al. "Amidated joining peptide in the human pituitary, gut, adrenal gland and bronchial carcinoids. Immunocytochemical and immunochemical evidence." Peptides 11.1 (1990): 149-161. Tested in Human, PubMed ID: 2188229

Van Berkum, F. N., et al. "Bone mass in women with primary biliary cirrhosis: the relation with histological stage and use of glucocorticoids." Gastroenterology 99.4 (1990): 1134-1139. Tested in Human, PubMed ID: 2394334

Buchan, A. M. J. "Effect of diabetes in the BB Wistar rat on the peptidergic component of the enteric innervation." Digestion 46.Suppl. 2 (1990): 142-147. Tested in Rat, PubMed ID: 2262048

Pipeleers-Marichal, Miriam, et al. "Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the Zollinger-Ellison syndrome." New England Journal of Medicine 322.11 (1990): 723-727. Tested in Human, PubMed ID: 1968616

Ottaviani, Enzo, and Andrea Cossarizza. "Immunocytochemical evidence of vertebrate bioactive peptide-like molecules in the immuno cell types of the freshwater snail Plianorbarius corneus(L.)(Gastropoda, Pulmonata)." FEBS letters 267.2 (1990): 250-252. Tested in Snail, PubMed ID: 1696211

Slowik, F., et al. "Intrasellar hamartoma associated with pituitary adenoma." Acta neuropathologica 80.3 (1990): 328-333. PubMed ID: 2399812

Lazarov, Nikolai, and Christo Chouchkov. "Localization of somatostatin-like immunoreactive fibres in the trigeminal principal sensory nucleus of the cat." Acta histochemica 89.1 (1990): 91-97. Tested in Cat, PubMed ID: 1981294

Cooley, A. J., et al. "Malignant jugulotympanic paraganglioma in a dog." Journal of comparative pathology 102.4 (1990): 375-383. Tested in Dog, PubMed ID: 2365852

Aramant, Robert, et al. "Neuronal markers in rat retinal grafts." Developmental Brain Research 53.1 (1990): 47-61. Tested in Rat, PubMed ID: 1972041

Tashiro, Takashi, et al. "Neurons in the mesencephalic trigeminal nucleus of the cat." Neuroscience Research Supplements 11 (1990): S136. Tested in Cat.

Antonini, A., and C. J. Shatz. "Relation between putative transmitter phenotypes and connectivity of subplate neurons during cerebral cortical development." European Journal of Neuroscience 2.9 (1990): 744-761. PubMed ID: 12106275

Larsen, Jens Nicolai Brink, et al. "Somatostatin and prosomatostatin in the retina of the rat: an immunohistochemical, in-situ hybridization, and chromatographic study." Visual neuroscience 5.05 (1990): 441-452. Tested in Rat, PubMed ID: 1981146

Albin, Roger L., et al. "Striatal and nigral neuron subpopulations in rigid Huntington's disease: Implications for the functional anatomy of chorea and rigidity‐akinesia." Annals of neurology 27.4 (1990): 357-365. Tested in Human, PubMed ID: 1972318

Pataky, D. M., S. B. Curtis, and A. M. J. Buchan. "The co-localization of neuropeptides in the submucosa of the small intestine of normal Wistar and non-diabetic BB rats." Neuroscience 36.1 (1990): 247-254. Tested in Rat, PubMed ID: 1699158

Feldman, Susan C., Michael R. Harris, and Lois K. Laemle. "The maturation of the somatostatin systems in the rat visual cortex." Peptides 11.6 (1990): 1055-1064. Tested in Rat, PubMed ID: 1982348

McCarson, Kenneth E., and Barry D. Goldstein. "Time course of the alteration in dorsal horn substance P levels following formalin: blockade by naloxone." Pain 41.1 (1990): 95-100. PubMed ID: 1693764

Teitelbaum, Daniel H., et al. "Alteration in gastrointestinal peptide tissue levels in rejecting small bowel transplants." Journal of pediatric surgery 24.7 (1989): 629-633. Tested in Rat, PubMed ID: 2474067

Moga, Margaret M., Clifford B. Saper, and Thackery S. Gray. "Bed nucleus of the stria terminalis: cytoarchitecture, immunohistochemistry, and projection to the parabrachial nucleus in the rat." Journal of comparative neurology 283.3 (1989): 315-332. Tested in Rat, PubMed ID: 2568370

Bowers, Cyril Y., et al. "Combinations having synergistic growth hormone releasing activity and methods for use thereof." U.S. Patent No. 4,880,778. 14 Nov. 1989.

Barbareschi, M., et al. "Duodenal gangliocytic paraganglioma." Virchows Archiv A 416.1 (1989): 81-89.

Smiley, John F., and Scott F. Basinger. "Glycine high-affinity uptake labels a subpopulation of somatostatin-like immunoreactive cells in theRana pipiens retina." Brain research 495.1 (1989): 31-44. Tested in Rana Pipiens (Frog), PubMed ID: 2789090

De Lanerolle, N. C., et al. "Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy." Brain research 495.2 (1989): 387-395. Tested in Human, PubMed ID: 2569920

Robertson, Brita, and Gunnar Grant. "Immunocytochemical evidence for the localization of the GM1 ganglioside in carbonic anhydrase-containing and RT 97-immunoreactive rat primary sensory neurons." Journal of neurocytology 18.1 (1989): 77-86. Tested in Rat, PubMed ID: 2496205

Martinez, A., A. C. Villaro, and P. Sesma. "Microscopic study of the pyloric caeca of the starfish Marthasterias glacialis (Echinodermata): finding of endocrine cells." Journal of Morphology 202.2 (1989): 151-164. Tested in Starfish.

Alba, Y., et al. "Neuroendocrine Complexes in the Gut of the Snail Helix aspersa." Journal of morphology 199.3 (1989): 313-325. Tested in Snail.

Seglen, Per O., et al. "Neuroendocrine dysdifferentiation and bombesin production in carcinogen-induced hepatocellular rat tumours." Carcinogenesis 10.1 (1989): 21-25. Tested in Rat, PubMed ID: 2910524

Walker, Lary C., et al. "Peptidergic neurons in the basal forebrain magnocellular complex of the rhesus monkey." Journal of Comparative Neurology 280.2 (1989): 272-282. Tested in Monkey, PubMed ID: 2466877

Mitrofanis, John, Stephen R. Robinson, and Jan M. Provis. "Somatostatinergic neurones of the developing human and cat retinae." Neuroscience letters 104.1 (1989): 209-216. Tested in Human and Cat, PubMed ID: 2573013

Haynes, Laurence W., and Frances M. Semenenko. "The trophic responses of avian sensory gangliain vitro to N-acetylated and des-acetyl forms of α-melanocyte stimulating hormone (α-MSH) are qualitatively distinct." International journal of developmental neuroscience 7.6 (1989): 623-632. PubMed ID: 2557733

Shobu, Ryuji. "Changes of plasma insulin glucagon and somatostatin in portal blood and morphological changes of islets of Langerhans after hepatectomy in dogs." Gastroenterologia Japonica 23.4 (1988): 442-447. Tested in Dog, PubMed ID: 2903109

Epstein, M. L., et al. "Cholinergic neurons of the chicken ciliary ganglion contain somatostatin." Neuroscience 25.3 (1988): 1053-1060. Tested in Chicken, PubMed ID: 2457184

Rizk, Sherif L., et al. "Elevated creatine phosphokinase MB in a patient with neuroendocrine carcinoma of the colon—Evidence for a tumor marker." Diseases of the Colon & Rectum 31.4 (1988): 318-322. PubMed ID: 3359901

Kakucska, I., et al. "Gabaergic innervation of somatostatin-containing neurosecretory cells of the anterior periventricular hypothalamic area: A light and electron microscopy double imunolabelling study." Neuroscience 25.2 (1988): 585-593.    PubMed ID: 2899859

Helke, C. J., and K. M. Hill. "Immunohistochemical study of neuropeptides in vagal and glossopharyngeal afferent neurons in the rat." Neuroscience 26.2 (1988): 539-551. PubMed ID: 2459628

Henken, Deborah B., et al. "In situ hybridization of mRNA for β-preprotachykinin and preprosomatostatin in adult rat dorsal root ganglia: comparison with immunocytochemical localization." Journal of neurocytology 17.5 (1988): 671-681. Tested in Rat, PubMed ID: 2905386

Gabriel, Steven M., Patricia E. Marshall, and Joseph B. Martin. "Interactions between growth hormone releasing hormone, somatostatin and galanin in the control of growth hormone secretion." Basic and Clinical Aspects of Growth Hormone. Springer US, 1988. 73-82.    

LaMotte, C. C. "Lamina X of primate spinal cord: distribution of five neuropeptides and serotonin." Neuroscience 25.2 (1988): 639-658. PubMed ID: 2456489

Card, J. Patrick, et al. "Localization of vasopressin-, vasoactive intestinal polypeptide-, peptide histidine isoleucine-and somatostatin-mRNA in rat suprachiasmatic nucleus." Cell and tissue research 252.2 (1988): 307-315. Tested in Rat, PubMed ID: 2898292

Kirchgessner, A. L., J. Dodd, and M. D. Gershon. "Markers shared between dorsal root and enteric ganglia." Journal of Comparative Neurology 276.4 (1988): 607-621. PubMed ID: 3143749

Walker, Lary C., et al. "Multiple transmitter systems contribute neurites to individual senile plaques." Journal of Neuropathology & Experimental Neurology 47.2 (1988): 138-144. PubMed ID: 2828554

Russo, Andrew F., et al. "Neuronal expression of chimeric genes in transgenic mice." Neuron 1.4 (1988): 311-320. Tested in Mouse, PubMed ID: 3078520

Weaver, Cyprian, Robert L. Sorenson, and Brian Kobienia. "Nonenzymatic isolation and culture of adult islets from atrophic pancreata of copper-deficient rats: A morphologic analysis." In vitro cellular & developmental biology 24.2 (1988): 108-116. Tested in Rat, PubMed ID: 2893782

Tornqvist, K., and B. Ehinger. "Peptide immunoreactive neurons in the human retina." Investigative ophthalmology & visual science 29.5 (1988): 680-686. Tested in Human, PubMed ID: 2452801

Sagar, S. M., and P. E. Marshall. "Somatostatin-like immunoreactive material in associational ganglion cells of human retina." Neuroscience 27.2 (1988): 507-516. Tested in Human, PubMed ID: 3217002

Bowker, Robert M., and Louise C. Abbott. "The origins and trajectories of somatostatin reticulospinal neurons: a potential neurotransmitter candidate of the dorsal reticulospinal pathway." Brain research 447.2 (1988): 398-403. PubMed ID: 2898965

Lehman, M. N., et al. "Circadian rhythmicity restored by neural transplant. Immunocytochemical characterization of the graft and its integration with the host brain." The Journal of neuroscience 7.6 (1987): 1626-1638. Tested in Hamster, PubMed ID: 3598638

Mufson, E. J., et al. "Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons." Brain research 417.2 (1987): 385-388. Tested in Rat, PubMed ID: 2888515

Cotter, John R., and Lois K. Laemle. "Distribution of somatostatinlike immunoreactivity in the brain of the little brown bat (Myotis lucifugus)." American journal of anatomy 180.3 (1987): 280-294. Tested in Bat, PubMed ID: 2893536

Molinari M, Hendry SH, Jones EG.; Distributions of certain neuropeptides in the primate thalamus; Brain Research,426(2):270-289 (1987), Tested in Monkey, PubMed ID: 2446708

Watts, Alan G., and Larry W. Swanson. "Efferent projections of the suprachiasmatic nucleus: II. Studies using retrograde transport of fluorescent dyes and simultaneous peptide immunohistochemistry in the rat." Journal of Comparative Neurology 258.2 (1987): 230-252. Tested in Rat, PubMed ID: 2438309

Bowker, Robert M. "Evidence for the co-localization of somatostatin-and methionine-enkephalin-like immunoreactivities in raphe and gigantocellularis nuclei." Neuroscience letters 81.1 (1987): 75-81. PubMed ID: 2892158

Jordan, Freddie L., and W. Eric Thomas. "Identification of somatostatin-containing neurons in primary cultures of rat cerebral cortex." Neuroscience letters 77.3 (1987): 249-254. Tested in Rat, PubMed ID: 2886959

Theriault, Elizabeth, and Dennis Landis. "Morphology of striatal neurons containing VIP‐like immunoreactivity." Journal of Comparative Neurology 256.1 (1987): 1-13. PubMed ID: 2434535

Philippe, J., W. L. Chick, and J. F. Habener. "Multipotential phenotypic expression of genes encoding peptide hormones in rat insulinoma cell lines." Journal of Clinical Investigation 79.2 (1987): 351. Tested in Rat, PubMed ID: 2879852

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Product Reviews

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Reviewed by Dan_Tylee
04/24/2012 - 09:32:00 AM
Strong, Cell-Specific Labeling
Tissue: Maccaca fasciscularis, perfused with saline and 4% paraformaldehyde, dehydrated through increase sucrose gradients, sectioned at 40 um.

Method: Immunocytochemistry on free floating sections. Incubated with ImmunoStar's primary antibody at a concentration of 1:1000 for 4 days in 10% normal goat serum (in 0.1M PO4 buffer with .3% Triton X-100). Rinsed, then incubated with Vector Lab's biotinylated goat anti-rabbit secondary antibody (#BA-1000) for 40 minutes at room temperature in the same 10% normal goat serum solution. Rinsed, then incubated with Vector's standard peroxidase kit (#PK-4000) for 60 minutes at room temperature in 0.1M PO4 buffer with 0.3% Triton X-100. Rinsed, then developed using the instructions for the kit.

Results: Strong, cell-specific labeling. Crisp, punctuate cell bodies. Low background signal. Extremely helpful for delineating the boundaries of the lateral core of the bed nucleus of the stria terminalis (BNST).


Daniel Tylee
Department of Neurobiology &amp; Anatomy
University of Rochester - School of Medicine and Dentistry