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Gastrin Antibody

Gastrin Antibody
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Price: $210.00
Product ID : 20055
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Description

The antibody has a proven strong staining using a 1/2000-1/3000 dilution with biotin-streptavidin/HRP technique in human stomach/antrum.

The specificity of the antiserum was evaluated by soluble pre-adsorption with the peptides in question at a final concentration of 10-6 M. Gastrin-17 immunolabeling was completely abolished by pre-adsorption with Gastrin 1 and big Gastrin and partially abolished by CCK-8. Pre-adsorption with the following peptides resulted in no loss of immunostaining: motilin, secretin, PHI-27, bombesin, VIP and GIP.

Photo Description: IHC image of parietal cells in the human stomach staining for gastrin (above, low magnification image; below high magnification image). The tissue was formalin fixed and embedded in paraffin for microtome sectioning. Sections at RT in 10% goat serum in PBS, followed by 3% hydrogen peroxide before standard IHC procedure. Primary antibody was incubated at 1:3000 for 48 hours, goat anti-rabbit secondary was subsequently added for 1 hour after washing with PBS. Light microscopy staining was achieved with standard biotin-streptavidin/HRP procedure and DAB chromogen and hemotoxylin counterstain in the low magnification image. 

Gastrin human antrum

Host: Rabbit

Quantity / Volume:  100 µL

State: Lyophilized Whole Serum

Reacts With: Human

Availability: In Stock

Alternate Names:  GAS; Gastrin 17; Gastrin component III; G17; preprogastrin

Gene Symbol / ID, Accession #:  GAST,2520

 

Download Product Spec. SheetGastrin Antibody

 

Journal References:


Luo, Jiing‐Chyuan, et al. "Gastric mucosal injury in systemic lupus erythematosus patients receiving pulse methylprednisolone therapy." British journal of clinical pharmacology 68.2 (2009): 252-259. Tested in Human, PubMed ID: 19694746

Yang, Qi, et al. "Requirement of Math1 for secretory cell lineage commitment in the mouse intestine." Science 294.5549 (2001): 2155-2158. Tested in Mouse, PubMed ID: 11739954

Ito, Kyoko, et al. "Acute parietal and chief cell changes induced by a lethal dose of lipopolysaccharide in mouse stomach before thrombus formation." Toxicologic pathology 28.2 (2000): 304-309. Tested in Mouse, PubMed ID: 10805148

Hunyady, Béla, et al. "Gastrin-producing endocrine cells: a novel source of histamine in the rat stomach." Endocrinology 139.10 (1998): 4404-4415. Tested in Rat, PubMed ID: 9751525

Wenig, Bruce M., et al. "Pancreatic mucinous cystic neoplasm with sarcomatous stroma: a report of three cases." The American journal of surgical pathology 21.1 (1997): 70-80. PubMed ID: 8990143

Ooi, Akishi, et al. "An unusual case of multiple gastric carcinoids associated with diffuse endocrine cell hyperplasia and parietal cell hypertrophy." Endocrine pathology 6.3 (1995): 229-237. Tested in Human, PubMed ID: 12114744

Klimstra, David S., et al. "Acinar cell carcinoma of the pancreas: a clinicopathologic study of 28 cases." The American journal of surgical pathology 16.9 (1992): 815-837. Tested in Human, PubMed ID: 1384374

TUBBS, RAYMOND R., RICHARD G. FARMER, and CLAUDIO FIOCCHI. "Colonic vasoactive intestinal peptide nerves in inflammatory bowel disease." Gastroenterology 102 (1992): 1242-1251.

Burrell, M. A., A. C. Villaro, and P. Sesma. "Evidence for the colocalization of gastrin/CCK-and PYY/PP-immunoreactive substances in the small intestine of the lizardPodarcis hispanica: Immunocytochemical and ultrastructural study." General and comparative endocrinology 88.1 (1992): 40-49. Tested in Lizard, PubMed ID: 1426962

Vittoria, Alfredo, et al. "Immunocytochemistry of paraneurons in the female urethra of the horse, cattle, sheep, and pig." The Anatomical Record 233.1 (1992): 18-24. Tested in Horse, Cattle, Sheep, Pig. PubMed ID: 1351370

Stanisz, A. N. D. R. E., and STEPHEN M. Collins. "Increased levels of substance P in myenteric plexus in Trichinella-infected rats." Gastroenterology 102 (1992): 1913-1919. Tested in Rat, PubMed ID: 1375178

Hayashi, Hiroyuki, Akishi Ooi, and Isao Nakanishi. "Biological and clinicopathological significance of endocrine differentiation of gastric adenocarcinoma evaluated by double immunohistochemical labeling for chromogranin A and bromodeoxyuridine." Japanese journal of clinical oncology 20.4 (1990): 339-348. PubMed ID: 1704442

Sithigorngul, Paisarn, Antony OW Stretton, and Cynthia Cowden. "Neuropeptide diversity in Ascaris: an immunocytochemical study." Journal of Comparative Neurology 294.3 (1990): 362-376. PubMed ID: 2341616

Chejfec, G., et al. "Pulmonary blastoma with neuroendocrine differentiation in cell morules resembling neuroepithelial bodies." Histopathology 17.4 (1990): 353-358. PubMed ID: 2124206

Burke, Allen P., et al. "Carcinoids of the duodenum: a histologic and immunohistochemical study of 65 tumors." The American journal of surgical pathology 13.10 (1989): 828-837. Tested in Human, PubMed ID: 2476943

Bauer, F. Eckhard, et al. "Long-acting somatostatin analog controls acid and gastrin secretion in benign, not in malignant, Zollinger-Ellison syndrome." Journal of clinical gastroenterology 11.3 (1989): 282-286. PubMed ID: 2754214

Seglen, Per O., et al. "Neuroendocrine dysdifferentiation and bombesin production in carcinogen-induced hepatocellular rat tumours." Carcinogenesis 10.1 (1989): 21-25. Tested in Rat, PubMed ID: 2910524

Sahlin, Karin. "Gastrin/CCK-like immunoreactivity in Hatschek's groove ofBranchiostoma lanceolatum(Cephalochordata)." General and comparative endocrinology 70.3 (1988): 436-441. PubMed ID: 3417119

Müller, Justus, Thomas Kirchner, and Hans Konrad Müller-Hermelink. "Gastric endocrine cell hyperplasia and carcinoid tumors in atrophic gastritis type A." The American journal of surgical pathology 11.12 (1987): 909-917. PubMed ID: 3318512

Sano, Toshiaki, et al. "Growth Hormone-Releasing Hormone (GHRH)-Secreting Pancreatic Tumor in a Patient with Multiple Endocrine Neoplasia Type." The American journal of surgical pathology 11.10 (1987): 810-819. PubMed ID: 2889383

Hawkins, K. L., et al. "Immunocytochemistry of normal pancreatic islets and spontaneous islet cell tumors in dogs." Veterinary Pathology Online 24.2 (1987): 170-179. Tested in Dog, PubMed ID: 2883753

Isidori, A., and M. Mazzetti. "ENDORPHINS IN THE MALE REPRODUCTIVE TRACT ANDREA FABBRI, LUCIO GNESSI, COSTANZO MORETTI, ROSANGELA FERRETTI, VINCENZO BONIFACIO*, CARLO FORESTA**, ANNA DI LUCA, FRANCESCO REDI and FRANCO FRAIOLI. V Clinica Medica Universita'di Roma" La Sapienza", Italy." Opioid peptides in the periphery: proceedings of the International Symposium on Opioid Peptides in Periphery under the patronage of the Italian National Council of Research held in Rome, Italy, on May 23-25, 1984. Vol. 18. Elsevier Science & Technology, 1984.

MULHOLLAND, MICHAEL W., et al. "Relationship of Antral Gastrin Cells and Serum Gastrin to Thyroid Function in the Rat*." Endocrinology 114.3 (1984): 840-844. Tested in Rat, PubMed ID: 6697967

COHN, DAVID V., et al. "Selective Localization of the Parathyroid Secretory Protein-I/Adrenal Medulla Chromogranin A Protein Family in a Wide Variety of Endocrine Cells of the Rat*." Endocrinology 114.6 (1984): 1963-1974. Tested in Rat, PubMed ID: 6233131

Sasek, C. A., V. S. Seybold, and R. P. Elde. "The immunohistochemical localization of nine peptides in the sacral parasympathetic nucleus and the dorsal gray commissure in rat spinal cord." Neuroscience 12.3 (1984): 855-873. Tested in Rat, PubMed ID: 6206440

Fallon, James H., and Kim B. Seroogy. "Visual and auditory pathways contain cholecystokinin: evidence from immunofluorescence and retrograde tracing." Neuroscience letters 45.1 (1984): 81-87. PubMed ID: 6374513

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