CCK-8 (Cholecystokinin Octapeptide) Antibody

The antibody has a proven strong indirect immunofluorescent staining at a 1/100-1/200 dilution and a strong Biotin-Streptavidin/HRP immunostaining at a 1/500-1/1000 dilution in rat hypothalamus and spinal cord.

The specificity of the antiserum was examined by soluble pre-adsorption with the peptides in question at a final concentration of 10-6M CCK-8 immunolabeling was completely abolished by pre-adsorption with CCK-8, gastrin 17 and gastrin 34. Pre-adsorption with the following peptides resulted in no reduction of immunostaining: α-CGRP, Ÿ-CGRP, neurotensin, somatostatin, substance P, leucine enkephalin, methionine enkephalin, VIP, neuropeptide Y, gastric inhibitory polypeptide, bombesin, glucagon, peptide YY, and FMRF amide.

Host: Rabbit

Quantity / Volume:  100 µL

State: Lyophilized Whole Serum

Reacts With: Deep Sea Fish, Mouse, Rat

Availability: In Stock

Antigen: Available at Sigma Aldrich, Catalog # C2901


Download Product Spec. Sheet:  CCK-8 (Cholecystokinin Octapeptide) Antibody

Journal References:

Anxiety-like behavior is modulated by a discrete subpopulation of interneurons in the basolateral amygdala, W.A. Truit, P.L. Johnson, A.D. Dietrich, S.D. Fitz, and A. Shekhar, Neuroscience, 160, 284–294, 2009, rat

Cholecystokinin Directly Inhibits Neuronal Activity of PrimaryGonadotropin Releasing Hormone Cells (GnRH-1) Through CCK-1R, Paolo Giacobini and Susan Wray1, Endocrinology, 2006.

Cholecystokinin Modulates Migration of Gonadotropin-Releasing Hormone-1 Neurons , Giacovini P, Kopin AS, Philip M. B, Mercer LD, Fasolo A, Wray S, The Journal of NeuroScience, 24(20), 4737-4748, 2004.

Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation, Shroyer, Walis,Venken ,Bellen, Zoghbi , GENES & DEVELOPMENT, 19, 2412-2417, 2005.

Reversed Somatodendritic Ih Gradient in a Class of Hippocampal Neurons with Pyramidal Morphology, James B Bullis, Terrance D Jones and Nicholas P Poolos, Neurobiology and Behavior, 2006.

The Organization of the Inner Retina in a Pure-Rod Deep-Sea Fish, Hirt, Wagner, Brain, Behavior, and Evolution, 65, 157-167, 2005.

FGF10 signaling controls stomach morphogenesis, Pia Nyeng, Gitte Anker Norgaard, Sune Kobberup, and Jan Jensen, Dev Biol., 303, 295-310, 2007, Tested in mouse.

Prenatal Expression Of Cholecystokinin (Cck) In The Central Nervous System (Cns) Of Mouse, Paolo Giacobini, and Susan Wray, Neurosci Lett., 438, 96-101, 2008, Tested in mouse.