Alpha-MSH (Melanocyte Stimulating Hormone) Antibody

The ImmunoStar alpha melanocyte stimulating hormone antiserum was quality control tested using standard immunohistochemical methods. The antiserum demonstrates strongly positive labeling of rat pituitary using biotin/avidin-HRP techniques.

Recommended primary dilutions are 1/100-1/200 in PBS/0.3% Triton X-100 - FITC Technique and 1/4000-1/6000 in PBS/0.3% Triton X-100 - Bn/Av-HRP Technique. Staining is completely eliminated by pretreatment of the diluted antibody with 100 ug/mL of alpha-MSH.

Host: Rabbit

Quantity / Volume: 100 µL

State: Lyophilized Whole Serum

Reacts With: Cat, Guinea Pig, Hamster, Mouse, Rat

Availability: In Stock

Alternate Names:  POMC; proopiomelanocortin 

Gene Symbol / ID, Accession #:  POMC,5443

Download Product Spec Sheet: Alpha-MSH (Melanocyte Stimulating Hormone) Antibody

Journal References:

Immunohistochemical localization of putative neurotransmitters within the feline nucleus tractus solitarii; B. Maley, R. Elde; Neuroscience,7(10):2469–2490, 1982, Tested in Cat, IFC, Cites ImmunoNuclear AKA ImmunoStar, PubMed ID: 6184644

Food deprivation-induced changes in body fat mobilization after neonatal monosodium glutamatetreatment; Claudia Leitner and Timothy J. Bartness; American Journal of Physiology, 294:R775-R783, 2008, Tested in Hamster, PubMed ID: 18094070

Acute brown adipose tissue temperature response to cold in monosodium glutamate-treated Siberian hamsters; Claudia Leitner, Timothy J. Bartness; Brain Research, 1292:3 8 – 5 1, 2009, Tested in Hamster, PubMed ID: 19643091

Arcuate nucleus destruction does not bl deprivation-induced increases in food foraging and hoardingock food; ; Brain Research,1323:94-108, 2010, Tested in Hamster, PubMed ID: 20138163

Cannabinoid-Induced Hyperphagia: Correlation With Inhibition Of Proopiomelanocortin Neurons; Jennie Ho, Jeremy M. Cox, and Edward J. Wagner; Physiol Behav.,92(3):507-519, 2007, Tested in Guinea Pig, PubMed ID: 17532014

PI3K integrates the action of insulin and leptin on hypothalamic neurons; Allison Wanting Xu, Christopher B. Kaelin, Kiyoshi Takeda, Shizuo Akira, Michael W. Schwartz, and Gregory S. Barsh; The Journal of Clinical Investigation,115:951-958, 2005, Tested in Mouse, PubMed ID: 15761497

Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene; Kwon-Yul Ryu, Jacob C. Garza, Xin-Yun Lu, Gregory S. Barsh, and Ron R. Kopito; PNAS, 105:4016-4021, 2008, Tested in Mouse, PubMed ID: 18299572

Brainstem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections; Zheng, Patterson, Phifer, Berthoud; Am J Physiol Regul Integr Comp Physiol, 869:(1-29), 2004, Tested in Rat, PubMed ID: 15746303

Hypothalamic proopiomelanocortin (POMC) neurons ; Bjorn Meister, Burcak Gomuc¸ Elisabet Suarez, Yuko Ishii, Katrin Durr and Linda Gillberg ; European Journal of Neuroscience,24:2731-2740, 2006, Tested in Rat, PubMed ID: 17156199